DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5038 and IFIT5

DIOPT Version :9

Sequence 1:NP_650451.1 Gene:CG5038 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_036552.1 Gene:IFIT5 / 24138 HGNCID:13328 Length:482 Species:Homo sapiens


Alignment Length:264 Identity:63/264 - (23%)
Similarity:104/264 - (39%) Gaps:78/264 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   421 QRATDWLNEEQLFKSALQVCPDNAKVHYNIA----------RLATDMGNNTK------------- 462
            :|...|....:|.|.||:|.|.::.:|:.:.          :.||.  |..|             
Human   260 RRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATH--NRPKGKDKLKVDELISS 322

  Fly   463 AFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGK 527
            |..|:..|:|....:..|..:|.|:|.|.||.|.||:..|.||:                     
Human   323 AIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALR--------------------- 366

  Fly   528 YDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAE--ALHHWQHAVALNPRQPKAWANILTML 590
                |.:.....|::     .:|:.|. :.|..|.:|  |:||:..|:.:..|.|     :.|.|
Human   367 ----LENITDDHKHQ-----IHYHYGR-FQEFHRKSENTAIHHYLEALKVKDRSP-----LRTKL 416

  Fly   591 DNKGLQDDAL-RISNQALQHLPNDVSILFIRANVLG---KLK-HYTEAEAIYKRVIELEPHNTLY 650
            .:      || ::|.:.|.|...||..|    :.||   ||: ...:|...|::..:::|.|..:
Human   417 TS------ALKKLSTKRLCHNALDVQSL----SALGFVYKLEGEKRQAAEYYEKAQKIDPENAEF 471

  Fly   651 HTNL 654
            .|.|
Human   472 LTAL 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5038NP_650451.1 DUF1736 258..331 CDD:285594
TPR 442..701 CDD:223533 55/243 (23%)
TPR_1 444..477 CDD:278916 9/55 (16%)
TPR repeat 444..472 CDD:276809 8/50 (16%)
TPR_17 466..499 CDD:290167 12/32 (38%)
TPR repeat 480..506 CDD:276809 12/25 (48%)
TPR repeat 511..541 CDD:276809 1/29 (3%)
TPR_1 512..545 CDD:278916 2/32 (6%)
TPR_1 546..577 CDD:278916 9/32 (28%)
TPR repeat 546..574 CDD:276809 9/29 (31%)
TPR repeat 580..608 CDD:276809 6/28 (21%)
TPR repeat 614..642 CDD:276809 8/31 (26%)
TPR repeat 647..677 CDD:276809 3/8 (38%)
IFIT5NP_036552.1 TPR_12 49..116 CDD:315987
TPR 1 51..84
TPR repeat 53..79 CDD:276809
TPR repeat 84..133 CDD:276809
TPR 2 94..127
TPR 3 138..173
TPR repeat 138..168 CDD:276809
PEP_TPR_lipo <157..470 CDD:274350 61/257 (24%)
TPR 4 181..214
TPR repeat 214..244 CDD:276809
TPR 5 249..282 8/21 (38%)
TPR repeat 249..277 CDD:276809 5/16 (31%)
Interaction with the 5'-triphosphate group of PPP-RNA 254..260 63/264 (24%)
TPR repeat 282..333 CDD:276809 8/52 (15%)
TPR 6 338..371 14/57 (25%)
TPR repeat 338..366 CDD:276809 12/27 (44%)
TPR 7 376..410 9/39 (23%)
TPR repeat 376..405 CDD:276809 9/34 (26%)
TPR 8 435..468 9/36 (25%)
TPR repeat 435..463 CDD:276809 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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