DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc4 and Tmtc3

DIOPT Version :10

Sequence 1:NP_650451.1 Gene:Tmtc4 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_001103483.1 Gene:Tmtc3 / 237500 MGIID:3036255 Length:920 Species:Mus musculus


Alignment Length:756 Identity:228/756 - (30%)
Similarity:348/756 - (46%) Gaps:149/756 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 ILVLICLLCYG----CGGLSGAKFVFDDTVAIVKNRDVN-SLPTNWTAIFTHDFWGASLLSSDSH 77
            ::|.:...||.    ||      |||||..||:.|:|:: |.|..  .:|.:||||..:....||
Mouse    16 LIVSVVAACYWNSLFCG------FVFDDVSAILDNKDLHPSTPLK--TLFQNDFWGTPMSEERSH 72

  Fly    78 KSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAALF 142
            ||:||||.|.|...|.|..|.......||.:.|.|.:::..::.| |::.:    |.::::|.||
Mouse    73 KSYRPLTVLTFRLNYLLSELKPMSYHLLNTVFHAVVSVIFLKVCR-LFLDK----RSSMIAALLF 132

  Fly   143 AAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLGPQTG------GLIMLLTAVGMLFKE 201
            |.||||||||:||||||||:..:..|...|   :.|...||...      .|.:.|.||..|.||
Mouse   133 AVHPIHTEAVTGVVGRAELLSSVFFLAAFL---SYTKSKGPDNSIVWTPIVLTVFLVAVATLCKE 194

  Fly   202 SAVTI-----------------PMSCVLLDYFQNGYYHLRFKDQWSLLRTRISYLFYLLGTLGLL 249
            ..:|:                 ||.|.:...|..|...:..    |:|:|.:..:..:|.||.|:
Mouse   195 QGITVVGICCVYEVFVAQGYTLPMLCTVAGQFLRGKGSIPL----SMLQTLVKLIVLMLSTLLLV 255

  Fly   250 TARLWWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTN 314
            ..|:.....:.|.|...|||.|.:. ..||.|:..|||.:|.||:|.|..||.||.:|.:.|:.:
Mouse   256 VVRVQVIQSQLPVFTRFDNPAAVSP-TPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIES 319

  Fly   315 IWDLR---------LQGVIGFYSIVLVALMNFRRLPG-----MMLALGLMIVPFLPASGIIC-VG 364
            ..|:|         ..|.:|.:|:         |.||     :::||.||.:||:|||.:.. ||
Mouse   320 FLDVRNLATFAFFCFLGALGIFSL---------RYPGDSSKTVLMALCLMALPFIPASNLFFPVG 375

  Fly   365 FVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENT----HWRTALRILLMLLFSVMMVRTRQRATD 425
            ||:|||.|||||:|||:|..:|   |...|.::.    .|     :.|.::.....::|..|..|
Mouse   376 FVVAERVLYVPSMGFCILVAHG---WQKISNKSVLKKLSW-----VCLSMVILTHALKTLHRNWD 432

  Fly   426 WLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYR- 489
            |.:|..||.|||:|..:|||:..|:.....:..|..||.:::.:|..:.|:...|.||:|..|: 
Mouse   433 WESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFEKALKYFLQATHVQPDDIGAHMNVGRTYKN 497

  Fly   490 ------------------------------------------------EHGQLSTAEEYIRLALQ 506
                                                            ...:|..|::..|.|:.
Mouse   498 LNRTREAEASYMLAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAIS 562

  Fly   507 AYPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQH 571
            ..|.|..|:::.|.:.....|..||..:|.|||:...|.|..:||:..:|:|.|...|||.::..
Mouse   563 MRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVYIELKEPNEALKNFNR 627

  Fly   572 AVALNPRQPKAWANILTMLDNKG---LQDDALRISNQALQHLPNDVSILFIRANVLGKL----KH 629
            |:.|||:...|..|...::...|   |:.:|.:.....:...|.|.:..|    .||.|    |.
Mouse   628 ALELNPKHKLALFNSAILMQESGEVKLRPEARKRLLNYVNEEPQDANGYF----NLGMLAMDDKK 688

  Fly   630 YTEAEAIYKRVIELEP--HNTLYHTNLGVLYHRWDKTQEAI 668
            .:|||:..|:.|:|:|  .:.|:  ||.:||.:..|..:|:
Mouse   689 DSEAESWMKKAIKLQPDFRSALF--NLALLYSQTAKELKAL 727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc4NP_650451.1 TMTC_DUF1736 258..331 CDD:462468 28/81 (35%)
LapB 431..675 CDD:442196 75/296 (25%)
TPR repeat 444..472 CDD:276809 7/27 (26%)
TPR repeat 480..506 CDD:276809 9/74 (12%)
TPR repeat 511..541 CDD:276809 10/29 (34%)
TPR repeat 546..574 CDD:276809 10/27 (37%)
TPR repeat 580..608 CDD:276809 5/30 (17%)
TPR repeat 614..642 CDD:276809 9/31 (29%)
TPR repeat 647..677 CDD:276809 7/22 (32%)
Tmtc3NP_001103483.1 TMTC_DUF1736 263..336 CDD:462468 25/73 (34%)
TPR 444..673 CDD:440225 51/228 (22%)
TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 451..484 8/32 (25%)
TPR repeat 451..479 CDD:276809 7/27 (26%)
TPR repeat 484..528 CDD:276809 5/43 (12%)
TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 485..518 5/32 (16%)
TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 534..567 5/32 (16%)
TPR repeat 535..562 CDD:276809 4/26 (15%)
LapB 549..804 CDD:442196 55/185 (30%)
TPR repeat 567..597 CDD:276809 10/29 (34%)
TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 568..601 9/32 (28%)
TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 602..635 13/32 (41%)
TPR repeat 602..630 CDD:276809 10/27 (37%)
TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 673..706 12/36 (33%)
TPR repeat 673..702 CDD:276809 10/32 (31%)
TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 707..740 7/23 (30%)
TPR repeat 707..735 CDD:276809 7/23 (30%)
TPR repeat 741..770 CDD:276809
TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 742..775
TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 776..809
TPR repeat 776..799 CDD:276809
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..897
Blue background indicates that the domain is not in the aligned region.

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