DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5038 and Ttc13

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001360868.1	Gene:	Ttc13 / 234875	MGIID:	2384573	Length:	845	Species:	Mus musculus

Alignment Length:	303	Identity:	70/303 - (23%)
Similarity:	119/303 - (39%)	Gaps:	77/303 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 YDSSTENTHWRTALR---ILLMLLFSVMMVRTRQRATDWLNEE-QLFKSALQVC--PDNAKVHYN 449
            ||.:..  |:.|.|:   .|:..::...:...::...|..|.| .||:.:..:.  ||..:|...
Mouse   144 YDEAIR--HFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVIALEPDRPEVFEQ 206

  Fly   450 IARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQL-------STAEEYIRLALQA 507
            .|.:.:.:|...:|.....:||:|.|:        ..|||..|.|       :||.|..:.:|:.
Mouse   207 RAEILSPLGRINEAVNDLTKAIQLQPS--------ARLYRHRGTLYFISEDYATAHEDFQQSLEL 263

  Fly   508 YPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHA 572
            ....|.|.:..|:....:|...:|:.::::|||.:.:|...|.::|..|.|...:..|...:|.|
Mouse   264 NRNQPTAMLYKGLTFFHRGLLKEAIEAFKEALKQKVDFIDAYKSLGQAYRELGNFDAATESFQKA 328

  Fly   573 VALNPRQPKAWANILTMLDNKGLQDDALRISNQALQHLPNDVSILFIRANVL---GKLKHYTEAE 634
            :.||                                  .|.|..|.:|..:|   |.|:   ||.
Mouse   329 LLLN----------------------------------QNHVQTLQLRGMMLYHHGSLQ---EAL 356

  Fly   635 AIYKRVIELEPHNT-------LYHTNLGVLYHRWDKTQEAIEA 670
            ..:||.::|||:|.       |.|..:|..|       |.|:|
Mouse   357 KNFKRCLQLEPYNEVCQYMKGLSHVAMGQFY-------EGIKA 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594
		TPR	442..701	CDD:223533	58/246 (24%)
		TPR_1	444..477	CDD:278916	8/32 (25%)
		TPR repeat	444..472	CDD:276809	5/27 (19%)
		TPR_17	466..499	CDD:290167	11/39 (28%)
		TPR repeat	480..506	CDD:276809	8/32 (25%)
		TPR repeat	511..541	CDD:276809	7/29 (24%)
		TPR_1	512..545	CDD:278916	8/32 (25%)
		TPR_1	546..577	CDD:278916	8/30 (27%)
		TPR repeat	546..574	CDD:276809	7/27 (26%)
		TPR repeat	580..608	CDD:276809	0/27 (0%)
		TPR repeat	614..642	CDD:276809	10/30 (33%)
		TPR repeat	647..677	CDD:276809	8/31 (26%)
Ttc13	NP_001360868.1	PEP_TPR_lipo	104..>403	CDD:274350	70/303 (23%)
		TPR repeat	132..156	CDD:276809	4/13 (31%)
		TPR repeat	164..195	CDD:276809	5/30 (17%)
		TPR repeat	201..229	CDD:276809	5/27 (19%)
		TPR repeat	234..262	CDD:276809	8/27 (30%)
		TPR repeat	267..297	CDD:276809	7/29 (24%)
		TPR repeat	302..329	CDD:276809	6/26 (23%)
		TPR repeat	336..364	CDD:276809	10/30 (33%)
		TPR repeat	370..397	CDD:276809	7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839908
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840