DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5038 and Kdm6a

DIOPT Version :9

Sequence 1:NP_650451.1 Gene:CG5038 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster
Sequence 2:XP_006527657.1 Gene:Kdm6a / 22289 MGIID:1095419 Length:1476 Species:Mus musculus


Alignment Length:349 Identity:74/349 - (21%)
Similarity:127/349 - (36%) Gaps:92/349 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   317 DLRLQGVIGFYSIVLVALMNFRRLPGMMLALGLMIVPFLPASGIICVGFVIAERTLYVPSIGFCL 381
            |.||.|.:.|:.       :..|:..::            ...:.|...:|.:....|.|..||.
Mouse    55 DSRLFGFVRFHE-------DGARMKALL------------GKAVRCYESLILKAEGKVESDFFCQ 100

  Fly   382 LSIYGFL----------YWYDSSTENTHWRTALRILLMLLFSVMMVRTRQRATDWLNEEQLFKSA 436
            |..:..|          |....|.::.:|:.|     ..|:.:.:|.....|..|  ..:.|:..
Mouse   101 LGHFNLLLEDYPKALSAYQRYYSLQSDYWKNA-----AFLYGLGLVYFHYNAFQW--AIKAFQEV 158

  Fly   437 LQVCPD--NAK-VHYNIA---RLATDMGNNTKAFQ----------------------------HY 467
            |.|.|.  .|| :|..:.   ::.||..::.|.||                            .|
Mouse   159 LYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKY 223

  Fly   468 HRAIELYPNY-----------ESALMNLGNLYREH-----GQLSTAE----EYIRLALQAYPAFP 512
            |.|.|.|...           .:.|..||  :..|     |..:|.|    :|::.:|:|.|...
Mouse   224 HSAKEAYEQLLQTENLSAQVKATILQQLG--WMHHTVDLLGDKATKESYAIQYLQKSLEADPNSG 286

  Fly   513 AAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNP 577
            .:|..||...|:.||...|..||.:::......|..:.::|.||.:|.:..:||..:..||.|:.
Mouse   287 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDH 351

  Fly   578 RQPKAWANILTMLDNKGLQDDALR 601
            ....||.::.|:.::.....||::
Mouse   352 GHAAAWMDLGTLYESCNQPQDAIK 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5038NP_650451.1 DUF1736 258..331 CDD:285594 5/13 (38%)
TPR 442..701 CDD:223533 48/214 (22%)
TPR_1 444..477 CDD:278916 13/64 (20%)
TPR repeat 444..472 CDD:276809 11/59 (19%)
TPR_17 466..499 CDD:290167 12/52 (23%)
TPR repeat 480..506 CDD:276809 8/34 (24%)
TPR repeat 511..541 CDD:276809 9/29 (31%)
TPR_1 512..545 CDD:278916 9/32 (28%)
TPR_1 546..577 CDD:278916 10/30 (33%)
TPR repeat 546..574 CDD:276809 8/27 (30%)
TPR repeat 580..608 CDD:276809 5/22 (23%)
TPR repeat 614..642 CDD:276809
TPR repeat 647..677 CDD:276809
Kdm6aXP_006527657.1 TPR repeat 95..123 CDD:276809 6/27 (22%)
TPR 108..401 CDD:223533 60/277 (22%)
TPR repeat 131..161 CDD:276809 7/36 (19%)
TPR repeat 166..196 CDD:276809 8/29 (28%)
TPR repeat 207..235 CDD:276809 5/27 (19%)
TPR repeat 287..314 CDD:276809 9/26 (35%)
TPR repeat 319..349 CDD:276809 9/29 (31%)
TPR repeat 354..380 CDD:276809 5/22 (23%)
JmjC 1151..1215 CDD:214721
JmjC 1185..1293 CDD:334913
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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