DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and F38B6.6

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_509123.2	Gene:	F38B6.6 / 185454	WormBaseID:	WBGene00018175	Length:	690	Species:	Caenorhabditis elegans

Alignment Length:	680	Identity:	235/680 - (34%)
Similarity:	361/680 - (53%)	Gaps:	37/680 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLPTNWTAIFTHDFWGASLLSSDSHKSFRP 82
            :|:||.|.........|..|||||..:||.|..||. ......||:.||||.|:.||:||||:||
Worm    32 LLILISLSIIPYLSCLGGDFVFDDAESIVNNPIVNG-KDPLLQIFSRDFWGRSISSSNSHKSYRP 95

  Fly    83 LTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSL-YVPEVSTARWAILSAALFAAHP 146
            :||..|...|.|...|......:|::.|.|.||:.::|.:.| ::.:....  |..::.|||.||
Worm    96 VTTFTFWLNYKLHETSTLGYHVVNIICHTVATLVFYKLGKQLEHIFDFFNI--AFSASILFAVHP 158

  Fly   147 IHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLGPQTGGLIMLLTAVGMLFKESA-VTIPMSC 210
            :|||||:.:.|||||:..:..|..|:|.|.|.     :.....:||..:..|.||.. :|||::
Worm   159 VHTEAVANITGRAELLMTIFSLAALILHVKNR-----EINCKFVLLVILSTLSKEQGLMTIPIA- 217

  Fly   211 VLLDYFQNGYYHLRFKDQWSLLRTRISYLFYLLGTLGLLTARLWWQDFETPTFKEVDNPVAHNEH 275
            :.:|:..:           ...|:....:..||..:|.|  |:....||...|.::|||.|....
Worm   218 ICIDFLAH-----------RSCRSNFVRMICLLVAIGFL--RMMVNGFEAAKFTKLDNPTAFLNS 269

  Fly   276 VLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLVALMNFRRL 340
            ...|.::..|:.:.:.:|::.|..||:|:::||:..:|.:||||....:..::||::.:......
Worm   270 KFYRMINYTYIWLYHAYLLVIPVNLCFDYSMGCISSITTMWDLRALSPVLIFTIVIIGVKFQNEC 334

  Fly   341 PGMMLALGLMIVPFLPASGI-ICVGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTA- 403
            ....|:..:.|:.|||||.| ..|||.||||.||:||.|||||....|      ...:.|::.|
Worm   335 RAFTLSSLMGIISFLPASNIFFTVGFSIAERVLYLPSAGFCLLCAIIF------KKLSVHFKNAD 393

  Fly   404 -LRILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHY 467
             |.|.|:||   ::.:|.:|:.:|..|..|:.|.|.|||.|||:|||:.::..|.|....|.::|
Worm   394 VLSITLILL---LISKTYRRSGEWKTELSLYSSGLSVCPTNAKIHYNLGKVLGDNGLTKDAEKNY 455

  Fly   468 HRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKAL 532
            ..||:|.|:||.||.|||||..:.|...|||..:..|:...|:|..|||||||.|....||.:|.
Worm   456 WNAIKLDPSYEQALNNLGNLLEKSGDSKTAESLLARAVTLRPSFAVAWMNLGISQMNLKKYYEAE 520

  Fly   533 ASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQD 597
            .|.:.:|..|.|.|.|.:|:|.||....|...|:..|::|..::|...::|.|:..:||:.....
Worm   521 KSLKNSLLIRPNSAHCLFNLGVLYQRTNRDEMAMSAWKNATRIDPSHSQSWTNLFVVLDHLSQCS 585

  Fly   598 DALRISNQALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWD 662
            ..:.:|.|||..:||:..:.....:...|..::|.||...|..|:|.|.:.|:|.|||:||.|..
Worm   586 QVIDLSYQALSSVPNESRVHMQIGSCHAKHSNFTAAENHIKSAIDLNPTSVLFHANLGILYQRMS 650

  Fly   663 KTQEAIEAYRTAISISAARATTARENLSKL 692
            :.:||...||..:::. ::...|::||.||
Worm   651 RHKEAESQYRIVLALD-SKNIVAKQNLQKL 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	22/72 (31%)
		TPR	442..701	CDD:223533	91/251 (36%)
		TPR_1	444..477	CDD:278916	13/32 (41%)
		TPR repeat	444..472	CDD:276809	10/27 (37%)
		TPR_17	466..499	CDD:290167	17/32 (53%)
		TPR repeat	480..506	CDD:276809	12/25 (48%)
		TPR repeat	511..541	CDD:276809	14/29 (48%)
		TPR_1	512..545	CDD:278916	14/32 (44%)
		TPR_1	546..577	CDD:278916	10/30 (33%)
		TPR repeat	546..574	CDD:276809	10/27 (37%)
		TPR repeat	580..608	CDD:276809	7/27 (26%)
		TPR repeat	614..642	CDD:276809	5/27 (19%)
		TPR repeat	647..677	CDD:276809	12/29 (41%)
F38B6.6	NP_509123.2	DUF1736	251..325	CDD:285594	22/73 (30%)
		TPR_11	431..497	CDD:290150	28/65 (43%)
		TPR_1	432..465	CDD:278916	13/32 (41%)
		TPR repeat	432..460	CDD:276809	10/27 (37%)
		TPR_17	455..486	CDD:290167	16/30 (53%)
		TPR_11	467..531	CDD:290150	27/63 (43%)
		TPR repeat	467..494	CDD:276809	12/26 (46%)
		TPR repeat	499..529	CDD:276809	14/29 (48%)
		TPR_11	500..565	CDD:290150	25/64 (39%)
		TPR_1	500..532	CDD:278916	14/31 (45%)
		TPR repeat	534..560	CDD:276809	9/25 (36%)
		TPR repeat	568..596	CDD:276809	7/27 (26%)
		TPR_11	601..666	CDD:290150	20/64 (31%)
		TPR repeat	601..631	CDD:276809	6/29 (21%)
		TPR repeat	636..664	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I7392
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32796
Inparanoid	1	1.050	371	1.000	Inparanoid score	I1222
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52291
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0006261
OrthoInspector	1	1.000	-	-		oto17210
orthoMCL	1	0.900	-	-		OOG6_105345
Panther	1	1.100	-	-	LDO	PTHR44227
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2852
SonicParanoid	1	1.000	-	-		X4542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.910