DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5038 and DNAAF4

DIOPT Version :9

Sequence 1:NP_650451.1 Gene:CG5038 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_570722.2 Gene:DNAAF4 / 161582 HGNCID:21493 Length:420 Species:Homo sapiens


Alignment Length:249 Identity:53/249 - (21%)
Similarity:99/249 - (39%) Gaps:53/249 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   429 EEQLFKSALQVCPDNAKVHY-----NIA--RLATDMGNNTKAFQHYHRAIELYPNYESALMNLGN 486
            ||:|.:...|:..:..|:.|     |:|  .||....|:...|..     :|..:...|..::|:
Human   178 EEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTE-----KLKEDSIPAPRSVGS 237

  Fly   487 L------------YREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEKAL 539
            :            .|| .|::..||::....:|..|     ||..|.:....|.::....:.|  
Human   238 IKINFTPRVFPTALRE-SQVAEEEEWLHKQAEARRA-----MNTDIAELCDLKEEEKNPEWLK-- 294

  Fly   540 KYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWAN-ILTMLDNKGLQDDALRIS 603
                       :.||.....:.|..|::.:..|:.||.:.|..:.| ....|..|.|. .|:..|
Human   295 -----------DKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLH-KAIEDS 347

  Fly   604 NQALQHL---PNDVSILFIRANV-----LGKLKHYTEAEAIYKRVIELEPHNTL 649
            ::||:.|   ..|.:...::|:|     ..:|:.|.|....|:..::::|.|.:
Human   348 SKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSNKI 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5038NP_650451.1 DUF1736 258..331 CDD:285594
TPR 442..701 CDD:223533 49/236 (21%)
TPR_1 444..477 CDD:278916 9/39 (23%)
TPR repeat 444..472 CDD:276809 8/34 (24%)
TPR_17 466..499 CDD:290167 6/44 (14%)
TPR repeat 480..506 CDD:276809 7/37 (19%)
TPR repeat 511..541 CDD:276809 5/29 (17%)
TPR_1 512..545 CDD:278916 5/32 (16%)
TPR_1 546..577 CDD:278916 6/30 (20%)
TPR repeat 546..574 CDD:276809 5/27 (19%)
TPR repeat 580..608 CDD:276809 8/28 (29%)
TPR repeat 614..642 CDD:276809 6/32 (19%)
TPR repeat 647..677 CDD:276809 1/3 (33%)
DNAAF4NP_570722.2 Mediates interaction with ESR1 and STUB1. /evidence=ECO:0000269|PubMed:19423554 7..103
p23_DYX1C1_like 10..87 CDD:107226
TPR_11 289..353 CDD:290150 17/77 (22%)
TPR 1 290..323 8/45 (18%)
TPR repeat 290..318 CDD:276809 6/40 (15%)
TPR repeat 323..353 CDD:276809 9/30 (30%)
TPR 2 324..357 10/33 (30%)
TPR repeat 364..394 CDD:276809 6/29 (21%)
TPR 3 366..399 7/32 (22%)
TPR_1 367..399 CDD:278916 7/31 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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