DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and TMTC3

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_861448.2	Gene:	TMTC3 / 160418	HGNCID:	26899	Length:	914	Species:	Homo sapiens

Alignment Length:	826	Identity:	233/826 - (28%)
Similarity:	367/826 - (44%)	Gaps:	201/826 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILVLICLLCYG----CGGLSGAKFVFDDTVAIVKNRDVN-SLPTNWTAIFTHDFWGASLLSSDSH 77
            ::|.:...||.    ||      |||||..||:.|:|:: |.|..  .:|.:||||..:....||
Human    11 LIVGVVTACYWNSLFCG------FVFDDVSAILDNKDLHPSTPLK--TLFQNDFWGTPMSEERSH 67

  Fly    78 KSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAALF 142
            ||:||||.|.|...|.|..|.......||::.|.|.:::..::.: |::...|    :::::.||
Human    68 KSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCK-LFLDNKS----SVIASLLF 127

  Fly   143 AAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLGPQTG------GLIMLLTAVGMLFKE 201
            |.||||||||:||||||||:..:..|...|   :.|...||...      .|.:.|.||..|.||
Human   128 AVHPIHTEAVTGVVGRAELLSSIFFLAAFL---SYTRSKGPDNSIIWTPIALTVFLVAVATLCKE 189

  Fly   202 SAVTIPMSCVLLDYF-QNGY----------YHLRFKDQ--WSLLRTRISYLFYLLGTLGLLTARL 253
            ..:|:...|.:.:.| ..||          ..||.|..  :|:|:|.:..:..:..||.|:..|:
Human   190 QGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRV 254

  Fly   254 WWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDL 318
            .....:.|.|...|||.|.:. ..||.|:..|||.:|.||:|.|..||.||.:|.:.|:.::.|:
Human   255 QVIQSQLPVFTRFDNPAAVSP-TPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDI 318

  Fly   319 R---------LQGVIGFYSIVLVALMNFRRLPG-----MMLALGLMIVPFLPASGIIC-VGFVIA 368
            |         ..|::|.:||         |..|     :::||.||.:||:|||.:.. ||||:|
Human   319 RNLATFTFFCFLGMLGVFSI---------RYSGDSSKTVLMALCLMALPFIPASNLFFPVGFVVA 374

  Fly   369 ERTLYVPSIGFCLLSIYGFLYWYDSSTENT----HWRTALRILLMLLFSVMMVRTRQRATDWLNE 429
            ||.|||||:|||:|..:|   |...||::.    .|     |.|.::.....::|..|..||.:|
Human   375 ERVLYVPSMGFCILVAHG---WQKISTKSVFKKLSW-----ICLSMVILTHSLKTFHRNWDWESE 431

  Fly   430 EQLFKSALQVCPDNAKV----------------------------------HYNIARLATDMGNN 460
            ..||.|||:|..:|||:                                  |.|:.|...::...
Human   432 YTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496

  Fly   461 TKAFQHYHRAIELY--------------PNYESALMNLGNLYR-EHGQLSTAEEYIRLALQAYPA 510
            .:|.:.|..|..|.              ||:.:..:||.||.| ...:|..|::..|.|:...|.
Human   497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPD 561

  Fly   511 FPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVAL 575
            |..|:::.|.:.....|..||..:|.|||:...|.|..:||:..:::|.|...|||.::..|:.|
Human   562 FKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALEL 626

  Fly   576 NPR--------------------QPKAWANILTML----------------------DNKG---- 594
            ||:                    :|:|...:|:.:                      ||:.
Human   627 NPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWM 691

  Fly   595 -----LQDD--------------------ALRISNQALQHLPNDVSILFIRANVL-GKLKHYTEA 633
                 ||.|                    ||.|..:.|::.|:.:..|.::.::| .:.|....|
Human   692 KKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGA 756

  Fly   634 EAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISISA 679
            :..::|::|::|.|.....||.|:|.   :.::.::|.|..:...|
Human   757 KKCFERILEMDPSNVQGKHNLCVVYF---EEKDLLKAERCLLETLA 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	29/81 (36%)
		TPR	442..701	CDD:223533	73/359 (20%)
		TPR_1	444..477	CDD:278916	10/80 (13%)
		TPR repeat	444..472	CDD:276809	8/61 (13%)
		TPR_17	466..499	CDD:290167	12/47 (26%)
		TPR repeat	480..506	CDD:276809	9/26 (35%)
		TPR repeat	511..541	CDD:276809	10/29 (34%)
		TPR_1	512..545	CDD:278916	9/32 (28%)
		TPR_1	546..577	CDD:278916	10/30 (33%)
		TPR repeat	546..574	CDD:276809	9/27 (33%)
		TPR repeat	580..608	CDD:276809	11/78 (14%)
		TPR repeat	614..642	CDD:276809	5/28 (18%)
		TPR repeat	647..677	CDD:276809	7/29 (24%)
TMTC3	NP_861448.2	DUF1736	259..331	CDD:312047	25/72 (35%)
		TPR 1	412..445		11/32 (34%)
		TPR_11	<435..802	CDD:330823	78/368 (21%)
		TPR 2	446..479		2/32 (6%)
		TPR repeat	446..474	CDD:276809	2/27 (7%)
		TPR repeat	479..523	CDD:276809	7/43 (16%)
		TPR 3	481..513		7/31 (23%)
		TPR 4	528..562		10/33 (30%)
		TPR repeat	530..557	CDD:276809	9/26 (35%)
		TPR repeat	562..592	CDD:276809	10/29 (34%)
		TPR 5	563..596		9/32 (28%)
		TPR repeat	597..625	CDD:276809	9/27 (33%)
		TPR 7	668..701		4/32 (13%)
		TPR repeat	668..696	CDD:276809	2/27 (7%)
		TPR repeat	701..731	CDD:276809	4/29 (14%)
		TPR 8	703..735		5/31 (16%)
		TPR 9	736..770		7/33 (21%)
		TPR repeat	736..765	CDD:276809	5/28 (18%)
		TPR repeat	771..799	CDD:276809	6/30 (20%)
		TPR 10	772..804		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..891
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820