Protein Alignment Tmtc4 and TMTC2

DIOPT Version :10

• Sequence 1: NP_650451.1
• Gene: Tmtc4 / 41867
• FlyBaseID: FBgn0038324
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_689801.1
• Gene: TMTC2 / 160335
• HGNCID: 25440
• Length: 836
• Species: Homo sapiens
• Alignment Length: 829
• Identity: 230/829 - (27%)
• Similarity: 367/829 - (44%)
• Gaps: 184/829 - (22%)

  Fly    35 AKFVFDDTVAIVKNRDVNSLP-TNWTAIFTHDFWGASLLSSDSHKSFRPLTTLMFHCEYALLGLS 98
            |.|.:||:.||..|:|:  || |.||.||.:||||..|..|.||||:|||.||.|...:|:.||:
Human    21 ADFCYDDSRAIKTNQDL--LPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLN 83

  Fly    99 AAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAALFAAHPIHTEAVSGVVGRAEL-- 161
            ......:|:|||...|.|.....:.|    :....|..::..:||:||||||||:|:||||::
Human    84 PWSYHLVNVLLHAAVTGLFTSFSKIL----LGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGA 144

  Fly   162 -MFGMIHLLCLLLTVANTGRLGPQTGGLIM---LLTAVGMLFKESAVTIPMSCVLLDYFQNGYYH 222
             :|.::.|||.:...:..| ...:|.|..:   |.....||:||..||:.....:.|.|.  ::.
Human   145 SLFFLLSLLCYIKHCSTRG-YSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFV--FHR 206

  Fly   223 LRFKDQWSLLRTRISYLFYLLGTL------GLLTARLWWQDFETPTFKEVDNPVAHNEHVLTRGL 281
            |:.|.....:..|.:...:|..:|      .||.|||:|...:.|:|...|||.|.::.:|||.|
Human   207 LKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTL 271

  Fly   282 SQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYS-IVLVALMNFR------- 338
            :..||...|:||:|||..|.:||::..|.|:..:.|.|....:.||: ::|:|....:
Human   272 TFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRE 336

  Fly   339 -------------------------------------------------RLPG----MMLALGLM 350
                                                             :||.    ::|:|.|:
Human   337 CNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLL 401

  Fly   351 IVPFLPASGI-ICVGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTALRILLMLLF-- 412
            |:||:||:.: ..||||||||.||:||:|||||...|        ....:.:...|.|..|:|
Human   402 IIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVG--------ARALYVKVQKRFLKSLIFYA 458

  Fly   413 -SVMMV----RTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIE 472
             :.::|    :|..|..||.|||.|::|.::|.|  ||...|:..:.......::|...|..|:.
Human   459 TATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALY 521

  Fly   473 LYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEK 537
            ...|....|.|||.|.:|:.:.:.|..|.:||:.:.|...:|::|.||:...||:.::|..::.|
Human   522 YRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLK 586

  Fly   538 A-------LK----YRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQ--PKAWANIL-- 587
            .       ||    ::::...|.||:|.||.||..|.|||..::.|:...|||  |::..|::
Human   587 CSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGE 651

  Fly   588 ---------------------------------TMLDNKGLQDDALRISNQALQHLP-------- 611
                                             .:|...|.:.:|.::..:|::..|
Human   652 AYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMH 716

  Fly   612 --------------------------NDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLY 650
                                      .:..::|..|::|.:......||..|.....|.|:....
Human   717 YGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAA 781

  Fly   651 HTNLGVLYHRWDKTQEAIEAYRTAISISAARATTARENLSKLLKRLERE 699
            ..|||.:.|...:.|:|...|..|:.:......| :.||.||...:|::
Human   782 LMNLGAILHLNGRLQKAEANYLRALQLKPDDVIT-QSNLRKLWNIMEKQ 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc4	NP_650451.1	TMTC_DUF1736	258..331	CDD:462468	27/73 (37%)
		LapB	431..675	CDD:442196	70/325 (22%)
		TPR repeat	444..472	CDD:276809	6/27 (22%)
		TPR repeat	480..506	CDD:276809	10/25 (40%)
		TPR repeat	511..541	CDD:276809	10/40 (25%)
		TPR repeat	546..574	CDD:276809	13/27 (48%)
		TPR repeat	580..608	CDD:276809	6/62 (10%)
		TPR repeat	614..642	CDD:276809	6/27 (22%)
		TPR repeat	647..677	CDD:276809	8/29 (28%)
TMTC2	NP_689801.1	ArnT	<78..>198	CDD:441412	40/124 (32%)
		TMTC_DUF1736	247..318	CDD:462468	26/70 (37%)
		TPR	488..727	CDD:440225	53/240 (22%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	493..526		6/32 (19%)
		TPR repeat	493..521	CDD:276809	6/27 (22%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	527..560		11/32 (34%)
		TPR repeat	527..555	CDD:276809	10/27 (37%)
		TPR repeat	560..590	CDD:276809	8/29 (28%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	561..594		8/32 (25%)
		TPR repeat	595..634	CDD:276809	15/38 (39%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	606..639		14/32 (44%)
		TPR repeat	642..671	CDD:276809	2/28 (7%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	643..676		1/32 (3%)
		TPR	646..>819	CDD:440225	23/173 (13%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	677..710		5/32 (16%)
		TPR repeat	679..705	CDD:276809	4/25 (16%)
		TPR repeat	710..774	CDD:276809	6/63 (10%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	711..744		0/32 (0%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	745..778		8/32 (25%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	779..812		8/32 (25%)
		TPR repeat	779..807	CDD:276809	8/27 (30%)