Protein Alignment Tmtc4 and Tmtc4

DIOPT Version :10

• Sequence 1: NP_650451.1
• Gene: Tmtc4 / 41867
• FlyBaseID: FBgn0038324
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: XP_061501219.1
• Gene: Tmtc4 / 1275041
• VectorBaseID: AGAMI1_008709
• Length: 688
• Species: Anopheles gambiae
• Alignment Length: 695
• Identity: 316/695 - (45%)
• Similarity: 440/695 - (63%)
• Gaps: 40/695 - (5%)

  Fly    17 AILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLPTNWTAIFTHDFWGASLLSSDSHKSFR 81
            |:||...||.|| |.|.|. |||||:.|||||.||.::.|.:..:..|||||.:|....||||||
Mosquito    13 ALLVAASLLAYG-GSLYGT-FVFDDSAAIVKNMDVRNVATPFRDLLRHDFWGNNLTDPTSHKSFR 75

  Fly    82 PLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLY--VPEVSTARWAILSAALFAA 144
            |||.|.|..|..||||:|.|||.:||.||.:..||:::|.:.|:  ..:..|..||   |.:|..
Mosquito    76 PLTVLSFQLENRLLGLNAGHMKKVNLALHTLICLLVFKLYQVLWRDSGQFRTPFWA---AFIFTV 137

  Fly   145 HPIHTEAVSGVVGRAELMFGMIHLLCLLL---TVANTGRLGPQTGGLIMLLTAVGMLFKESAVTI 206
            ||||||||.|:||||:|:..:.:|..|||   .:|:..|........:.|||.:.|||||:.:|.
Mosquito   138 HPIHTEAVVGIVGRADLLAAIGYLTVLLLYQRWLASERRYRAVVYAGLFLLTVLSMLFKETGMTA 202

  Fly   207 PMSCVLLDYFQNGYYHLRFKDQWSLLRTRISYLFYLLGTLGLLTA--RLWWQDFETPTFKEVDNP 269
            .::|..:|..:...:.:...:.:::.|:|:..:| :|..|.|.|.  |||..|||:|.|..:|||
Mosquito   203 LVACGAIDLLKRINFRVPLAEFFTVHRSRLGRVF-ILACLSLATVALRLWIMDFESPRFHRMDNP 266

  Fly   270 VAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLVAL 334
            :......::|.|||.||..:|.||::||.||.:|||||.|.|:.::.|.|:..|:.||:  .:|:
Mosquito   267 IGATNSTISRLLSQSYLYWLNSWLLICPDWLSFDWALGSVPLLESVADYRILFVVLFYA--AIAV 329

  Fly   335 MNFRRLPG----MMLALGLMIVPFLPASGIICVGFVIAERTLYVPSIGFCLLSIYGFLYWYDSST 395
            :.||....    ::.:|.|.|||||||.|::.||||||||.||:||:|||.|...|
Mosquito   330 LAFRSCESKSREIITSLALAIVPFLPACGLVRVGFVIAERLLYLPSVGFCYLVAVG--------- 385

  Fly   396 ENTHWR------TALRILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLA 454
                ||      .|..|.|.||.::.:::|:.||.:|.:|:.||:|||:|||.||||:|||||||
Mosquito   386 ----WRRLIKRSVAFYIPLCLLCTMFILKTQSRAYEWTSEDLLFRSALRVCPHNAKVYYNIARLA 446

  Fly   455 TDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLG 519
            ||.|:...||..|.|||||:|.||:|.|||||||||..:|..||.::|.|::.:..||:||||||
Mosquito   447 TDQGDRATAFTFYRRAIELHPEYEAAHMNLGNLYRETHELDRAEWHLRRAIEIHEPFPSAWMNLG 511

  Fly   520 IVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWA 584
            |||:|:..:|.||.||::||:.:.|:|.|.||:||||::::..:.||.:|:.|:..|||..||||
Mosquito   512 IVQAARKDHDAALTSYQRALQLKPNYANCLYNLGNLYIDKQNSSMALRYWREAIQQNPRHSKAWA 576

  Fly   585 NILTMLDNKGLQDDALRISNQALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTL 649
            |||.:.||:|..:|.:|.|..||..||||.:|||.|||..|||..|..||::|.::|...|.:.:
Mosquito   577 NILALYDNRGRTEDIIRTSALALTFLPNDTAILFTRANAYGKLGQYETAESLYHQIIAARPDHAV 641

  Fly   650 YHTNLGVLYHRW-DKTQEAIEAYRTAISISAARATTARENLSKLL 693
            |..||||||||| .:..:|||.||.|:.:. ....:|:.||.||:
Mosquito   642 YRANLGVLYHRWGQRKAQAIEQYRAALRLD-PNLRSAKANLLKLM 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc4	NP_650451.1	TMTC_DUF1736	258..331	CDD:462468	32/72 (44%)
		LapB	431..675	CDD:442196	132/244 (54%)
		TPR repeat	444..472	CDD:276809	18/27 (67%)
		TPR repeat	480..506	CDD:276809	15/25 (60%)
		TPR repeat	511..541	CDD:276809	19/29 (66%)
		TPR repeat	546..574	CDD:276809	12/27 (44%)
		TPR repeat	580..608	CDD:276809	14/27 (52%)
		TPR repeat	614..642	CDD:276809	13/27 (48%)
		TPR repeat	647..677	CDD:276809	16/30 (53%)
Tmtc4	XP_061501219.1	None