DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5038 and ifit5

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001135660.1	Gene:	ifit5 / 100216220	XenbaseID:	XB-GENE-5842099	Length:	473	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	76/375 - (20%)
Similarity:	146/375 - (38%)	Gaps:	69/375 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 VIAERTLYVPSIGFCL-LSIYGFLYWYDSSTENTHWRTALRILLMLLFSVMMVRTRQRATDWL-- 427
            ::.|..:....|.:.| .|.|.:|::|.:.:|::.         :.:..:..:.|:.:..:.|
Frog    79 ILTESKVLETDIKYLLTFSNYAWLHYYLNDSESSQ---------LYIDKINAIYTQSKGLEDLVQ 134

  Fly   428 ---NEEQ-----------------LFKSALQVCPDNAKVHYNIA----RLATDMGNNTKA----- 463
               |.||                 .|:.|::..||:.:.:..:|    ||....|.|..|
Frog   135 SETNGEQGWALMKFCGQYYERAKGCFEEAVKGNPDDPEWNTGLATVVCRLEEFRGRNCPAFKSVS 199

  Fly   464 FQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKY 528
            ||...||::|.|......:.|....:|..:...|.::|:.||:..|..|.....:.......||:
Frog   200 FQLLERAVKLNPKDSVIKVLLALKLQELKRQEEAMKHIKDALELTPDLPYVLRYVAKFYRRAGKF 264

  Fly   529 DKALASYEKALKYRANFAVCYYNMGNLY----LEQKRYAEALHHWQHAVALNPRQPKAWANILTM 589
            ::.:...:||:....|....::.:|..|    :::||..:|.:..|....:.....||..:....
Frog   265 EETIRVLKKAVSITPNSGFLHHQLGLCYRQMIIQRKRTGKANYRGQDTQEIKDLTEKAIFHFEMA 329

  Fly   590 LDNKGLQDDALRISNQALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIEL----EPHNTLY 650
            |:.|           :...|...|::.:::|:|      .|.:||..||:..||    |......
Frog   330 LEMK-----------KTFLHAHFDLADMYVRSN------QYQKAEETYKKATELITTPEHEKQQA 377

  Fly   651 HTNLGVLYHRWDKTQ-EAIEAYRTAISISAARATTARENLSKLLKRLERE 699
            |...|.......|:: ||:|.|:..:.|  ....|.|:.....|:|:..:
Frog   378 HLQYGKFLENSKKSEDEAVEQYKEGLRI--PDQNTHRQECEMCLRRIANQ 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594
		TPR	442..701	CDD:223533	60/276 (22%)
		TPR_1	444..477	CDD:278916	12/41 (29%)
		TPR repeat	444..472	CDD:276809	10/36 (28%)
		TPR_17	466..499	CDD:290167	7/32 (22%)
		TPR repeat	480..506	CDD:276809	5/25 (20%)
		TPR repeat	511..541	CDD:276809	5/29 (17%)
		TPR_1	512..545	CDD:278916	5/32 (16%)
		TPR_1	546..577	CDD:278916	6/34 (18%)
		TPR repeat	546..574	CDD:276809	6/31 (19%)
		TPR repeat	580..608	CDD:276809	4/27 (15%)
		TPR repeat	614..642	CDD:276809	7/27 (26%)
		TPR repeat	647..677	CDD:276809	7/30 (23%)
ifit5	NP_001135660.1	PEP_TPR_lipo	<144..>405	CDD:274350	58/277 (21%)
		TPR repeat	219..242	CDD:276809	5/22 (23%)
		TPR repeat	248..276	CDD:276809	5/27 (19%)
		TPR repeat	281..332	CDD:276809	9/50 (18%)
		TPR repeat	337..365	CDD:276809	9/33 (27%)
		TPR repeat	375..404	CDD:276809	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910