Protein Alignment Tmtc4 and tmtc4

DIOPT Version :10

• Sequence 1: NP_650451.1
• Gene: Tmtc4 / 41867
• FlyBaseID: FBgn0038324
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_001121486.1
• Gene: tmtc4 / 100158586
• XenbaseID: XB-GENE-5771787
• Length: 738
• Species: Xenopus tropicalis
• Alignment Length: 758
• Identity: 272/758 - (35%)
• Similarity: 404/758 - (53%)
• Gaps: 87/758 - (11%)

  Fly     4 LVHKATLHSMVCQAILVLICLLCYGCGGLS-GAKFVFDDTVAIVKNRDVNSLPTNWTAIFTHDFW 67
            |.|...|.|:.......|:..|.:.|...| ..:|||||:.||:.|:|:.. .|....::.||||
 Frog     7 LEHAIPLFSLSPFFAKCLVGTLAFVCFANSYNGRFVFDDSEAIINNKDLRG-ETPVADLWLHDFW 70

  Fly    68 GASLLSSDSHKSFRPLTTLMFHCEYALL-GLSAAHMKFLNLLLHCVNTLLMWRLIRSL------- 124
            |..|.|:.||||:||||.|.|...|.:. ||......|:|::|||:.::||..:...|
 Frog    71 GTKLSSNASHKSYRPLTVLTFRMNYHIAGGLHPVGFHFVNIVLHCLVSVLMLNVFSMLFGGMTCS 135

  Fly   125 -------YVPEVSTARWAILSAALFAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLG 182
                   |.|:.|     :|:|.|||.||:|||.|:|:||||:|:..    ||::|:.....|..
 Frog   136 HKGKQITYAPKAS-----LLAALLFAVHPVHTECVAGIVGRADLLCA----LCVVLSFLGYCRAL 191

  Fly   183 PQTGG---------LIMLLTAVGMLFKESAVTIPMSCVLLDYF---------------------Q 217
            |....         ..:||.||.||.||..:|:.....:.|.|                     :
 Frog   192 PGNNTTHSSVFWVMFSILLAAVAMLCKEQGITVLGLNAVFDVFVICKLNILECVQKVLRRDKTSE 256

  Fly   218 NGYYHLRFKDQWSLLRTRISYLFYLLGTLGLLTARLWWQDFET--PTFKEVDNPVAHNEHVLTRG 280
            |..:     |:..|. .|||    ||.:.|:....:.|:...|  |.|.|||||.:..:.:|.|.
 Frog   257 NNKF-----DRKGLF-VRIS----LLVSGGICMLYIRWRIMGTGPPAFTEVDNPASFADSLLVRV 311

  Fly   281 LSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLVALM-------NFR 338
            ::..|...:|.||:|||.|||:||::||:.|:.::.|.|:..::..: ..|:.||       |.:
 Frog   312 INYNYYYSLNGWLLLCPWWLCFDWSMGCIPLINSLSDWRVIALVALW-FCLLGLMYQALFSNNAQ 375

  Fly   339 RLPGMMLALGLMIVPFLPASGIIC-VGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRT 402
            :...:.|.||.:|:||||||.:.. ||||:|||.||:||:|:|:|    |.|.|.........:.
 Frog   376 KRRMLTLGLGFLIIPFLPASNLFFRVGFVVAERVLYLPSVGYCVL----FTYGYSKICRLIKNKK 436

  Fly   403 ALRILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHY 467
            .|...::.:..:.:||...|:..|.:||.||:||:.|||.|||||||:.:...|.|..|:|.:.|
 Frog   437 LLSAAILGIMVMNVVRCIYRSNQWKSEELLFRSAISVCPLNAKVHYNVGKNLADRGYQTEAIEFY 501

  Fly   468 HRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKAL 532
            ..::.|.|.|..|:.||||:.:|..||..|::.:..|:...|.|.||||||||||::...:::|.
 Frog   502 RESVRLNPKYVHAMNNLGNILKEKDQLQEAQQLLSRAVSIQPDFAAAWMNLGIVQNSLKYFEEAE 566

  Fly   533 ASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQD 597
            .||..|:|||..:..||||:|.||.:..|:.:||:.|::|..|.|....||.|::.::||.|...
 Frog   567 KSYLTAIKYRKKYPDCYYNLGRLYADLNRHVDALNAWRNATFLKPEHSLAWNNMIILMDNTGNLA 631

  Fly   598 DALRISNQALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWD 662
            .|..|..:||:.||||.||.|..||||||.:.|.|:|:::.:.||..|.:..||.||.||||||.
 Frog   632 KAEAIGREALKLLPNDHSITFSLANVLGKAQKYKESESLFLKAIEANPSSASYHNNLAVLYHRWG 696

  Fly   663 KTQEAIEAYRTAISISAARATTARENLSKLLKR----LEREAQ 701
            ....|.:.|..::.:..: |...:||.. ||||    |:::|:
 Frog   697 NLDLAKKHYEISMKLDPS-APGTKENYG-LLKRKFEQLQKKAR 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc4	NP_650451.1	TMTC_DUF1736	258..331	CDD:462468	27/74 (36%)
		LapB	431..675	CDD:442196	106/243 (44%)
		TPR repeat	444..472	CDD:276809	11/27 (41%)
		TPR repeat	480..506	CDD:276809	10/25 (40%)
		TPR repeat	511..541	CDD:276809	15/29 (52%)
		TPR repeat	546..574	CDD:276809	12/27 (44%)
		TPR repeat	580..608	CDD:276809	9/27 (33%)
		TPR repeat	614..642	CDD:276809	12/27 (44%)
		TPR repeat	647..677	CDD:276809	12/29 (41%)
tmtc4	NP_001121486.1	TMTC_DUF1736	288..362	CDD:462468	27/74 (36%)
		PilF	455..544	CDD:442297	36/88 (41%)
		TPR repeat	478..506	CDD:276809	11/27 (41%)
		TPR	505..706	CDD:440225	86/200 (43%)
		TPR repeat	514..540	CDD:276809	10/25 (40%)
		TPR repeat	545..575	CDD:276809	15/29 (52%)
		TPR repeat	580..606	CDD:276809	11/25 (44%)
		TPR repeat	614..642	CDD:276809	9/27 (33%)
		TPR repeat	647..677	CDD:276809	14/29 (48%)
		TPR repeat	682..710	CDD:276809	12/27 (44%)