DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5038 and tmtc3

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_001922486.4	Gene:	tmtc3 / 100150181	ZFINID:	ZDB-GENE-061221-2	Length:	932	Species:	Danio rerio

Alignment Length:	741	Identity:	232/741 - (31%)
Similarity:	363/741 - (48%)	Gaps:	86/741 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ICLL------CYG----CGGLSGAKFVFDDTVAIVKNRDVNSLPTN-WTAIFTHDFWGASLLSSD 75
            ||||      ||.    ||      |||||..||:.|:|:.  ||. ...:|.:||||..:....
Zfish     9 ICLLTGLVVGCYWNSLFCG------FVFDDVSAILDNKDLR--PTTPLKNLFLNDFWGTPMSEER 65

  Fly    76 SHKSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAA 140
            ||||:||||.|.|...|....|:::....||::||.|..:|.....|.|.  :.||   ::::..
Zfish    66 SHKSYRPLTVLTFRLNYLFSELNSSSYHLLNVVLHAVVCVLFLHFCRLLL--DRST---SLIATL 125

  Fly   141 LFAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLGPQTGGLI--------MLLTAVGM 197
            |||.||||||||:||||||||:..:..|...|....:.|     |...|        :.|.||..
Zfish   126 LFAVHPIHTEAVTGVVGRAELLSSIFLLAAFLAYTKSKG-----TDHSIVWTPIISTVFLVAVAT 185

  Fly   198 LFKESAVTIPMSCVLLDYF-QNGY----------YHLRFKD--QWSLLRTRISYLFYLLGTLGLL 249
            |.||..:|:...|.:.:.| ..|:          ..||.||  .:::|:|.:..:..::.||.|:
Zfish   186 LCKEQGITVIGICCIYEVFVAQGFTLPMLIDTLLQVLRGKDGFPYAVLQTLLKLIVLIISTLLLV 250

  Fly   250 TARLWWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTN 314
            ..|:.....:.|.|...|||.|.:. ..:|.|:..|||.:|.||:|.|..||.||.:|.:.||.:
Zfish   251 IIRVQVIQSQLPVFTRFDNPAAVSS-TPSRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLVES 314

  Fly   315 IWDLRLQGVIGFYSIV-LVAL----MNFRRLPGMMLALGLMIVPFLPASGIIC-VGFVIAERTLY 373
            :.|.|....:.||:.: |:|.    .|......:|:||.|:::||:|||.:.. ||||:|||.||
Zfish   315 LLDSRNLATLVFYTFLGLLAYHGLWYNHSSSKIIMMALSLIVLPFIPASNLFFPVGFVVAERVLY 379

  Fly   374 VPSIGFCLLSIYGF-LYWYDSSTENTHWRTALRILLMLLFSVMMVRTRQRATDWLNEEQLFKSAL 437
            |||:|||:|..||| |.......:...|     :|:.:|.:...|:|..|..||.:|..||.|||
Zfish   380 VPSMGFCVLVAYGFKLLSQKGGLKKMSW-----LLMGILLTTHAVKTFNRNWDWESEYTLFTSAL 439

  Fly   438 QVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEE-YI 501
            :|..:|||:..|:.....:..:..:|.:::.:|..:.|:...|.||:|..|:...:...||| |:
Zfish   440 KVNRNNAKLWNNVGHALENQNSYERALRYFLQATRVQPDDIGAHMNVGRTYKNLNRSREAEEAYL 504

  Fly   502 -------------RLALQAYPAFPAAWMNL-GIVQSAQGKYDKALASYEKALKYRANFAVCYYNM 552
                         :.|.:..|.....::|| .::::...:.::|...|.:|:..|.:|...|.:.
Zfish   505 IAKSLMPQIIPGKKYATRVAPNHLNVYINLANLIRANDSRLEEADQLYRQAISMRPDFKQAYISR 569

  Fly   553 GNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQD--DALRISNQALQHLPNDVS 615
            |.|.|:..:.:||...:..|:.|:......|.|:..:  |..::|  :|||..|:||...|....
Zfish   570 GELLLKMNKPSEAKDAYLRALELDHTNADLWYNLAIV--NIEMKDPSEALRNFNRALDLNPRHKL 632

  Fly   616 ILFIRANVL---GKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISI 677
            .||..|.::   |:.|...||...:...::.||.:...:.|||:|....::.:||....|.||.:
Zfish   633 ALFNSALLMQESGEAKLRPEANRRFLTYVKEEPDDANGYFNLGMLAMDANENEEAEHWMREAIHL 697

  Fly   678 SAARATTARENLSKLLKRLEREAQVM 703
            ... ..:|..||:.|..:.:||...:
Zfish   698 QPG-FRSALFNLALLYSQSQRELDAL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	27/73 (37%)
		TPR	442..701	CDD:223533	68/278 (24%)
		TPR_1	444..477	CDD:278916	6/32 (19%)
		TPR repeat	444..472	CDD:276809	5/27 (19%)
		TPR_17	466..499	CDD:290167	8/32 (25%)
		TPR repeat	480..506	CDD:276809	10/39 (26%)
		TPR repeat	511..541	CDD:276809	5/30 (17%)
		TPR_1	512..545	CDD:278916	6/33 (18%)
		TPR_1	546..577	CDD:278916	8/30 (27%)
		TPR repeat	546..574	CDD:276809	7/27 (26%)
		TPR repeat	580..608	CDD:276809	9/29 (31%)
		TPR repeat	614..642	CDD:276809	7/30 (23%)
		TPR repeat	647..677	CDD:276809	9/29 (31%)
tmtc3	XP_001922486.4	DUF1736	258..331	CDD:285594	27/73 (37%)
		TPR_11	<434..477	CDD:290150	12/42 (29%)
		TPR repeat	445..475	CDD:276809	6/29 (21%)
		TPR_1	446..479	CDD:278916	6/32 (19%)
		TPR	462..757	CDD:223533	64/264 (24%)
		TPR repeat	480..506	CDD:276809	9/25 (36%)
		TPR repeat	530..557	CDD:276809	5/26 (19%)
		TPR repeat	562..592	CDD:276809	8/29 (28%)
		TPR_1	564..596	CDD:278916	8/31 (26%)
		TPR_1	597..630	CDD:278916	11/34 (32%)
		TPR repeat	597..625	CDD:276809	9/29 (31%)
		TPR repeat	667..697	CDD:276809	9/29 (31%)
		TPR repeat	702..730	CDD:276809	6/21 (29%)
		TPR repeat	736..765	CDD:276809
		TPR_11	739..802	CDD:290150
		TPR repeat	771..794	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820