DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and tmtc2

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001096156.1	Gene:	tmtc2 / 100124656	XenbaseID:	XB-GENE-948541	Length:	836	Species:	Xenopus tropicalis

Alignment Length:	832	Identity:	242/832 - (29%)
Similarity:	367/832 - (44%)	Gaps:	188/832 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GAKFVFDDTVAIVKNRDVNSLP-TNWTAIFTHDFWGASLLSSDSHKSFRPLTTLMFHCEYALLGL 97
            ||.|.:||:.||..|:|:  || |.|..||.:||||..|..|.||||:|||.||.|...|.|.||
Frog    20 GADFCYDDSRAIKTNQDL--LPETPWNHIFFNDFWGTLLTHSGSHKSYRPLCTLSFRLNYLLGGL 82

  Fly    98 SAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAALFAAHPIHTEAVSGVVGRAELM 162
            .......:|:|||...|.|...|.::|:    .:..|.:::..|||:||||||||:|:||||::.
Frog    83 DPWSYHLVNILLHSAVTGLFTNLCKALF----GSGCWTLIAGLLFASHPIHTEAVAGIVGRADVG 143

  Fly   163 FGMIHLLCLLLTVANTGRLGPQTGGLIMLL-----TAVGMLFKESAVTIPMSCVLLDYFQNGYYH 222
            .|:..||.||..:.:....|........:|     .|..||:||..||:.....:.|.|.  ::.
Frog   144 AGLFFLLSLLCYMKHCSTRGYSLSSWCWILCAGFWAACSMLWKEQGVTVLAVSAVYDIFV--FHK 206

  Fly   223 LRFKDQWSLL--RTRISYLFYLLGTLGLLTA--------RLWWQDFETPTFKEVDNPVAHNEHVL 277
            |:.....|::  |..:|:.|    ::|||.|        |.:|.....|:|...|||.|..|.:|
Frog   207 LKMNQIISVVFKRKNVSFFF----SVGLLFAWGVVLLGVRFYWMGNTPPSFSNSDNPAADCEVLL 267

  Fly   278 TRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLVALMNFRRLPG 342
            ||.|:..||...|:||:.||..|.:||::..|.|:..|.|.|....:.|:  :|:.|:::..|.|
Frog   268 TRTLTFFYLPTKNLWLLFCPDTLSFDWSMDAVPLIKTIIDWRNIHTVAFH--ILLILLSYSSLKG 330

  Fly   343 ---------------------------------------------------------------MM 344
                                                                           ::
Frog   331 SAMKRDCNGKLFMNGKHNTNGHSCQSDLEHKNAEQKPVIASKLENGIKHHISHEMQLPSTKNIVV 395

  Fly   345 LALGLMIVPFLPASGI-ICVGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTALRILL 408
            |||.|:||||:|||.: ..||||||||.||:||:|||||...|....|..:.:|     .|:.||
Frog   396 LALSLLIVPFVPASNLFFYVGFVIAERVLYIPSMGFCLLVTVGARALYIKAQKN-----FLKSLL 455

  Fly   409 MLLFSVMMV----RTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHR 469
            ....:.::|    :|..|..||.|||.|::|.::|.|  ||...|:..:........:|...|..
Frog   456 FYATTALIVFYGLKTVVRNGDWKNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKIDEAENAYRN 518

  Fly   470 AIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALAS 534
            |:....|....|.|||.|.:|:.:.|.|..|.:||:.:.|...:.::|.||:...||:.::|..:
Frog   519 ALYYRSNMADMLYNLGLLLQENSKFSEALHYYKLAIGSRPTLASGYLNTGIILMNQGRTEEARRT 583

  Fly   535 YEKA-------LK----YRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQ--PKAWANI 586
            :.|.       ||    ::::...|.||:|.||.||.:|.:||..::.|:...|||  |::..|:
Frog   584 FLKCSEIPDENLKDPNAHKSSVTSCLYNLGKLYHEQGQYEDALIVYKEAIQKMPRQFSPQSLYNM 648

  Fly   587 L-----------------------------------TMLDNKGLQDDALRISNQALQHLPN---- 612
            :                                   .:|...|.:::|.|...:|:|..||
Frog   649 MGEAYMRLNLVSEAEHWYTESLKSKPDHIPAHLTYGKLLTLTGRKNEAERYFLKAIQLDPNKGNC 713

  Fly   613 ------------------------------DVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHN 647
                                          :..::|..|::|.:......||..||....|.|:.
Frog   714 YMHYGQFLLEEGRLLEAAEMAKKAAELDNSEFDVVFNAAHMLRQASLNEAAEKYYKLAAGLRPNY 778

  Fly   648 TLYHTNLGVLYHRWDKTQEAIEAYRTAISISAARATTARENLSKLLKRLERE 699
            .....|||.:.|...|.:||...|..|:.:....|.| :.||.||...:|::
Frog   779 PAALMNLGAILHLNGKLEEAESNYLRALQLKPDDAIT-QSNLRKLWNIMEKQ 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	27/72 (38%)
		TPR	442..701	CDD:223533	78/340 (23%)
		TPR_1	444..477	CDD:278916	6/32 (19%)
		TPR repeat	444..472	CDD:276809	6/27 (22%)
		TPR_17	466..499	CDD:290167	11/32 (34%)
		TPR repeat	480..506	CDD:276809	11/25 (44%)
		TPR repeat	511..541	CDD:276809	9/40 (23%)
		TPR_1	512..545	CDD:278916	9/43 (21%)
		TPR_1	546..577	CDD:278916	12/30 (40%)
		TPR repeat	546..574	CDD:276809	12/27 (44%)
		TPR repeat	580..608	CDD:276809	7/62 (11%)
		TPR repeat	614..642	CDD:276809	7/27 (26%)
		TPR repeat	647..677	CDD:276809	9/29 (31%)
tmtc2	NP_001096156.1	PMT_2	43..244	CDD:389829	74/210 (35%)
		DUF1736	247..316	CDD:369859	26/68 (38%)
		PEP_TPR_lipo	<461..821	CDD:274350	87/362 (24%)
		TPR repeat	493..521	CDD:276809	6/27 (22%)
		TPR repeat	526..556	CDD:276809	11/29 (38%)
		TPR repeat	561..589	CDD:276809	7/27 (26%)
		TPR repeat	601..634	CDD:276809	12/32 (38%)
		TPR repeat	642..671	CDD:276809	2/28 (7%)
		TPR repeat	676..706	CDD:276809	5/29 (17%)
		TPR repeat	779..807	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920