DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6218 and W06B4.2

DIOPT Version :9

Sequence 1:	NP_001262598.1	Gene:	CG6218 / 41863	FlyBaseID:	FBgn0038321	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_494789.1	Gene:	W06B4.2 / 173784	WormBaseID:	WBGene00021057	Length:	521	Species:	Caenorhabditis elegans

Alignment Length:	319	Identity:	107/319 - (33%)
Similarity:	168/319 - (52%)	Gaps:	25/319 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FGGVEGGATHSRLVICDESGQSVGATSGLGTNHWGIGIPECARRIADMVERA--KEEAGIPKETP 66
            :.|:|||||.|:|||.|........:|..|||.:........:||||.:...  ||:..|..
Worm   196 YAGIEGGATGSKLVIIDADTNQRYTSSTEGTNFFLTDHTIVCKRIADWILEVFEKEKLDIKN--- 257

  Fly    67 LTSLGLSLSGCEQEATNRELEQELRTTFPGLAQNYAVSSDTMGSMYT--ASSIGGMVLISGTGSN 129
            |.:|||.|||.|.|..|::.....|.....:.:|:.::||.:.::..  .....|:|||:||||:
Worm   258 LKALGLGLSGAEDEEFNKKFVDYFRQNHGNVTENFYLTSDAVMTLLANFPGEENGIVLIAGTGSS 322

  Fly   130 CLLRNPDGSTSNCGGWGNFLGDEGSAWYISYRAVKVVFDHMDNFEQS-AAPVEKTWSLIKEHFSL 193
            |.|:..|||....||||:.:||.|||::|:..|::::||..|.||:: ...|.|  .|:.:|:::
Worm   323 CRLKIRDGSVKGAGGWGHQIGDGGSAFWIARTAIQMLFDAEDGFEENFNTDVIK--QLLFKHYNI 385

  Fly   194 ETRLDMLPHCYAKFDKPFFANLCKKLSQNAENGDELARSLFREAGVHL---ARMILALLPNVHQD 255
            ..:..||.:.|:||:|...|:....|::..:  |......||.||..|   .|.:...|.|..:.
Worm   386 TDKTRMLDYLYSKFEKHKIADFTVSLAERTD--DAAVAEAFRRAGDVLGKHVRTVAKYLTNEDRK 448

  Fly   256 LVKSGDLSVVCVGSVWSSWDLLQEAFISELAKTTIDFDLKLVRI--TKSSAYGACYLGA 312
            :     ||:|.:|.|:.|||.||:.|::.|:.:.|:   |:|..  :.|.|.||..|.|
Worm   449 V-----LSIVQIGGVFQSWDALQQGFVASLSGSGIE---KIVMYEPSDSPAVGAAVLAA 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6218	NP_001262598.1	NBD_sugar-kinase_HSP70_actin	1..285	CDD:302596	97/288 (34%)
W06B4.2	NP_494789.1	AdoMet_MTases	10..155	CDD:388410
W06B4.2	NP_494789.1	NBD_sugar-kinase_HSP70_actin	195..500	CDD:388382	107/319 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156180
Domainoid	1	1.000	130	1.000	Domainoid score	I3250
eggNOG	1	0.900	-	-		E1_COG2971
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9720
Inparanoid	1	1.050	151	1.000	Inparanoid score	I2966
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005695
OrthoInspector	1	1.000	-	-		oto18336
orthoMCL	1	0.900	-	-		OOG6_102986
Panther	1	1.100	-	-	O	PTHR12862
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3943
SonicParanoid	1	1.000	-	-		X5377
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.780