DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS-m and Sars2

DIOPT Version :9

Sequence 1:	NP_001262599.1	Gene:	SerRS-m / 41862	FlyBaseID:	FBgn0021750	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_001099710.1	Gene:	Sars2 / 292759	RGDID:	1309456	Length:	518	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	164/434 - (37%)
Similarity:	238/434 - (54%)	Gaps:	51/434 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPTNSQLWRPLLLLRRQ-------RSHDAKAVEAPIHRPVPTSAQLDELERNVVVRHHKNNVPLI 60
            ||.....|:.|..||.|       :...|:||.|.:.:......|.|...:.:..|..:     |
  Rat    86 LPAIISTWQELRQLREQIQSLEAEKEAVAEAVRALLAKQDSNQVQKDPQYQGLRTRGRE-----I 145

  Fly    61 RSLIQELDAGDQHKLRQLQAELEQ----LPNATHPR-----------LRDYGEEPRELAQYVHRQ 110
            |..:..|    ..:..||:.|..|    |||.|||.           ||..|::|....|
  Rat   146 RKQLTPL----YPRETQLEEEFYQQALRLPNQTHPDTPVGDESQARVLRVVGDKPAFSFQ----- 201

  Fly   111 LTPQSRLKEFSELARALNLYRMDHLGNYTGHKSYYLTGQLATLEQAIIQYALQAVTEHGFKLISV 175
              |:..|    |:...|::.|...|.:.:||:||||.|..|.|:..::.:.|..:...||..::|
  Rat   202 --PRGHL----EIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLSKLVSRGFTPMTV 260

  Fly   176 PDILPKEVIESCGMRTEGERTQVYKLDTGEC----LSGTSEMALAGFFANKLLSEDQLPLKVTAV 236
            ||:|...|.|.|||......:|:|.:|....    |:||:|:.|||:|.:..::...||:::...
  Rat   261 PDLLRGAVFEGCGMTPNANPSQIYNIDPSRFEDLNLAGTAEVGLAGYFMDHAVASRDLPVRMVCA 325

  Fly   237 SRCYRAETSGLQEEKGIYRVHQFNKVEMFAICTE--EQSEAELEEFKNIEVDLFRRLGLNFRLLD 299
            |.||||||...:|..|:||||.|.|||||.:...  |||...||||.:::|::...|||:||:||
  Rat   326 STCYRAETDTGKEPWGLYRVHHFAKVEMFGVTGPGLEQSSQLLEEFLSLQVEILTELGLHFRVLD 390

  Fly   300 MPPCELGAPAYQKYDIEAWMPGRQMWGEISSCSNCTDYQARRLGIRYRRSADGQILHAHTINGTA 364
            ||..|||.|||:|:|||||||||..:||::|.|||||:|:|||.|.: .:..|::..|||:|.||
  Rat   391 MPTQELGLPAYRKFDIEAWMPGRGRYGEVTSASNCTDFQSRRLYIMF-ETETGELQFAHTVNATA 454

  Fly   365 TAIPRLLIALLESYQKEDG-IEIPAVLRPFMDNQELITRNKRIP 407
            .|:||:|||||||.|::|| :.:||.|:|:: ..:.||....:|
  Rat   455 CAVPRVLIALLESNQQKDGSVLVPAALQPYL-GTDRITAPTHVP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS-m	NP_001262599.1	SerS	60..404	CDD:223250	149/365 (41%)
SerRS-m	NP_001262599.1	class_II_aaRS-like_core	100..394	CDD:294192	131/300 (44%)
Sars2	NP_001099710.1	PRK05431	67..493	CDD:235461	163/428 (38%)
		Seryl_tRNA_N	67..172	CDD:299883	22/94 (23%)
		SerRS_core	185..485	CDD:238393	134/311 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343391
Domainoid	1	1.000	186	1.000	Domainoid score	I3272
eggNOG	1	0.900	-	-		E1_COG0172
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6073
Inparanoid	1	1.050	264	1.000	Inparanoid score	I2998
OMA	1	1.010	-	-		QHG54742
OrthoDB	1	1.010	-	-		D495094at33208
OrthoFinder	1	1.000	-	-		FOG0005193
OrthoInspector	1	1.000	-	-		oto95601
orthoMCL	1	0.900	-	-		OOG6_100275
Panther	1	1.100	-	-	LDO	PTHR11778
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3706
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770