DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SerRS-m and sars2

DIOPT Version :9

Sequence 1:	NP_001262599.1	Gene:	SerRS-m / 41862	FlyBaseID:	FBgn0021750	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	XP_002940400.1	Gene:	sars2 / 100485850	XenbaseID:	XB-GENE-969286	Length:	505	Species:	Xenopus tropicalis

Alignment Length:	417	Identity:	166/417 - (39%)
Similarity:	242/417 - (58%)	Gaps:	49/417 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LRRQRSHDAKAVEAPIHRPVPTSAQ-LDELERNVVVRHHKNNVPL-IRSLIQELDAGDQHKLRQL 78
            |..::|..||.|:   |..:....| |....|..::|....::.| :.:|.:|
Frog    97 LEEEKSAIAKEVK---HMVISEEKQNLQTNPRYALIRKRGKDIRLELSTLYKE------------ 146

  Fly    79 QAELE--------QLPNATHPRLRDYGEEPRELAQYVHRQLTPQSRLKEFS-------ELARALN 128
            ::.||        :|||.|||. ...|:|.:.      |.|.......||.       |:...|:
Frog   147 ESNLEGSFYPRALRLPNRTHPN-TPVGDESKA------RVLEVVGVKPEFDFKICGHLEIGEDLD 204

  Fly   129 LYRMDHLGNYTGHKSYYLTGQLATLEQAIIQYALQAVTEHGFKLISVPDILPKEVIESCGMRTEG 193
            :.|...|.:.:||:||||.|..:.|:.|::.:.:..:.:.||..:||||:|...|.|.|||:.:.
Frog   205 IIRQRRLSHVSGHRSYYLRGAGSLLQHALVNFTISKLVKKGFIPMSVPDMLRGAVFEGCGMQADA 269

  Fly   194 ERTQVYKLDTGE----CLSGTSEMALAGFFANKLLSEDQLPLKVTAVSRCYRAETSGLQEEKGIY 254
            ..:|||.:|..:    .|:||||:.:||||.:..:....||::....|.||||||...:|..|:|
Frog   270 HASQVYSVDPLQHPDLNLAGTSEVGIAGFFMDHAVMLQDLPVRTVCCSTCYRAETDTGRETWGLY 334

  Fly   255 RVHQFNKVEMFAICTEE---QSEAELEEFKNIEVDLFRRLGLNFRLLDMPPCELGAPAYQKYDIE 316
            |||.|.|||||.:...|   :|:..|:||..::.::|..|||:|::|:||..|||.|||:|||||
Frog   335 RVHHFTKVEMFGVTANESGIESQEMLDEFLGLQKEIFSELGLHFKVLEMPTQELGLPAYRKYDIE 399

  Fly   317 AWMPGRQMWGEISSCSNCTDYQARRLGIRYRRSADGQILHAHTINGTATAIPRLLIALLESYQKE 381
            ||||||..:|||||.|||||||:|||.|.|:|. ||::.||||:||||.|:||||||:|||.|::
Frog   400 AWMPGRGKYGEISSTSNCTDYQSRRLNIMYQRQ-DGELRHAHTVNGTACAVPRLLIAILESNQRK 463

  Fly   382 DG-IEIPAVLRPFMDNQELITRNKRIP 407
            || :.||.||:|:| ..::|.:.:.||
Frog   464 DGAVLIPEVLQPYM-GTDVIEKPRYIP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SerRS-m	NP_001262599.1	SerS	60..404	CDD:223250	153/366 (42%)
SerRS-m	NP_001262599.1	class_II_aaRS-like_core	100..394	CDD:294192	139/308 (45%)
sars2	XP_002940400.1	SbcC	<44..>151	CDD:223496	13/68 (19%)
sars2	XP_002940400.1	SerRS_core	177..477	CDD:238393	139/306 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I2960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6073
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2861
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D495094at33208
OrthoFinder	1	1.000	-	-		FOG0005193
OrthoInspector	1	1.000	-	-		oto102340
Panther	1	1.100	-	-	LDO	PTHR11778
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1456
SonicParanoid	1	1.000	-	-		X3706
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190