Protein Alignment Cyfip and Cyfip2

DIOPT Version :10

• Sequence 1: NP_650447.1
• Gene: Cyfip / 41861
• FlyBaseID: FBgn0038320
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: XP_006534524.1
• Gene: Cyfip2 / 76884
• MGIID: 1924134
• Length: 1278
• Species: Mus musculus
• Alignment Length: 1305
• Identity: 845/1305 - (64%)
• Similarity: 1026/1305 - (78%)
• Gaps: 58/1305 - (4%)

  Fly     1 MTEKITLADALSNVEVLDELSLPDEQPCIEAQPCSIIYKANFDTNFEDRNGFVTGIAKYIEEATT 65
            ||..:||.||||||::|:||.|||:|||||..|.||:|:|||||||||||.||||||:|||:||.
Mouse     1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATV 65

  Fly    66 HANLNVLLDEGQKHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQR 130
            |:::|.:|:||..:||||||||.|||||||.|.|||||||||||||||||.|||.||:.||||||
Mouse    66 HSSMNEMLEEGHDYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQR 130

  Fly   131 KAIEAFSGEVKRLCHAEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFL 195
            ||||.|..|||||||||:||||||||||||||||||||||||||||||.|||||:|.|:||||||
Mouse   131 KAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFL 195

  Fly   196 KVMSDSHTLQESQNLSMFLATQNKIRDTVKDTLEKIVGYEDLLSDVVNICVHMFETKMYLTPEEK 260
            :.|:|..::|||||||||||..|:|...:...||.|.|||:||:|:|||||..:|.||||||.||
Mouse   196 RKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEK 260

  Fly   261 HMLVKVMGFGLFLMDSDACNINKLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHF 325
            |||:|||||||:|||.:..||.|||.||:|.|.:||:.||.|:||||||||||....|||.|.|:
Mouse   261 HMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHY 325

  Fly   326 D--SSKWPLSSSNAISPQADLMVHLPQIREDHVKYISELARYTNEVTTT---VKENPSDAENRIT 385
            :  .|||..:.| :||||.::...:.|||:||:::|||||||:|....|   :....||.|.|..
Mouse   326 EENKSKWTCTQS-SISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYREL 389

  Fly   386 ADLALRGLQLLSEWTSVVTELYSWKLLHPTDHHQNKECPVEAEEYERATRYNYTSEEKFALIEVI 450
            .|||||||||||:|::.|.|:|||||:||||...||:||..|||||||||||||||||||.:|||
Mouse   390 FDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVI 454

  Fly   451 AMIKGLQVLMARIETVLCEAIRRNIYSELQDFVQLSLREPLRKAVKNKKDLIRSIIMSVRETSAD 515
            ||||||||||.|:|:|..:|||..||:.||||.|::||||||:||:.||:::.|::.::|:|..|
Mouse   455 AMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICD 519

  Fly   516 WQKGYEPTDDPVAKGKKDPDGGFRIQVPRLNVGPSSTQ-------------------------LY 555
            |:.|.||.:||..:|:|||.|||.|:|||..|||||||                         ||
Mouse   520 WEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLY 584

  Fly   556 MVRTMLESLIADKSGGKRTLRKDIDGNCLLQIDTFHKTSFYWSYLLNFSDTLQKCCDLSQLWYRE 620
            |||||||||||||||.|:|||..:||..:|.|:.|||.||::::|||.|:.||:||||||||:||
Mouse   585 MVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFRE 649

  Fly   621 FYLEMTMGRKVNKCLVRHQHNEECKDLITMEKRIQFPIEMSMPWILTDHILQTKEPSMMEFVLYP 685
            |:||:||||                       |||||||||||||||||||:||||||||:||||
Mouse   650 FFLELTMGR-----------------------RIQFPIEMSMPWILTDHILETKEPSMMEYVLYP 691

  Fly   686 LDLYNDSAYYALTVFRKQFLYDEVEAEVNLCFDQFVYKLSEQIFAHYKQLAGSIFLDKRFRLECE 750
            |||||||||||||.|:|||||||:|||||||||||||||::||||:||.:|||:.||||||.||:
Mouse   692 LDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECK 756

  Fly   751 VLGFNFQSYPRNNRYETLLKQRHVQLLGRSIDLNKLITQRINANMHKSIELAISRFEGNDITGIV 815
            ..|. ...||.:||||||||||||||||||||||:||||||:|.|:||::.||||||..|:|.||
Mouse   757 NYGV-IIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIV 820

  Fly   816 ELEGLLEANRICHKLLSKYLALDNFDGMVKEANHNVLAPYGRITLHVFVELNYDFLVNYCYNAAT 880
            |||.|||.||:.|:||.|::.||:||.|.:||||||.|||||||||||.|||:|||.|||||.:|
Mouse   821 ELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGST 885

  Fly   881 NRFIRTKVNLSSSQAIQREKPPQMSHYYLWGSKQLNAAYSTQYGQYTGFVGSPHFHAMCRLLGYQ 945
            |||:||.:..  :|..||:||..:..|||:|||.||.|||..|..|..|||.|||..:|||||||
Mouse   886 NRFVRTAIPF--TQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQ 948

  Fly   946 GIAVVMDIILKDIVKPLIQGSLLQFTKTLMIAMPKSCKLPRCEYGSPGVLSYYQAHLTDIVQYPD 1010
            ||||||:.:|| |||.|:||::||:.|||:..|||.|:|||.||||||:|.::...|.||::|.:
Mouse   949 GIAVVMEELLK-IVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAE 1012

  Fly  1011 AKTELFQSFREFGNSIIFCLLIEQALSQEEVCDLLHAALFQNIFPRPFCKENEKPEAKQKRLEAQ 1075
            .||::|||.||.||:|:|||||||||||||||||||||.||||.||.:.||.|:.|.:.|||||:
Mouse  1013 LKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAK 1077

  Fly  1076 FANLQIVSNVEKIGTAKQAMIAREGDLLTRERLCCGLSIFEVILNRVKSYLDDPVWCGPPPANGI 1140
            :|.|.:|..:|::||.:|..|||||||||:||||||||:|||||.|::|||.||:|.||||.||:
Mouse  1078 YAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGV 1142

  Fly  1141 IHVDECSEFHRLWSALQFVYCIPVRGTEYTIEELFGEGLNWAGCVMIVLLGQQRRFEALDFCYHI 1205
            :|||||.||||||||:||||||||...|:|.|:.||:|||||||.:||||||||||:..|||||:
Mouse  1143 MHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHL 1207

  Fly  1206 LRVQRVDGKDEDVKGIQLKRMVDRIRRFQVLNSQIFSILNKYLKGGDGEGSNVEHVRCFPPPQHP 1270
            |:|||.|||||.:|.:.||:|.||||::|:||:::|:|||||:|..:.:.|.|||||||.||.|.
Mouse  1208 LKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQ 1272

  Fly  1271 SVISS 1275
            |:.::
Mouse  1273 SLATT 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyfip	NP_650447.1	CYRIA-B_Rac1-bd	89..>267	CDD:462106	135/177 (76%)
		FragX_IP	386..1244	CDD:461799	568/882 (64%)
Cyfip2	XP_006534524.1	FragX_IP	388..1246	CDD:461799	568/884 (64%)