Protein Alignment Sra-1 and Cyfip1

DIOPT Version :9

• Sequence 1: NP_650447.1
• Gene: Sra-1 / 41861
• FlyBaseID: FBgn0038320
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: NP_001100987.1
• Gene: Cyfip1 / 308666
• RGDID: 1310332
• Length: 1253
• Species: Rattus norvegicus
• Alignment Length: 1281
• Identity: 839/1281 - (65%)
• Similarity: 1034/1281 - (80%)
• Gaps: 34/1281 - (2%)

  Fly     1 MTEKITLADALSNVEVLDELSLPDEQPCIEAQPCSIIYKANFDTNFEDRNGFVTGIAKYIEEATT 65
            |..::||.||||||::|:||.|||:|||||..|.|::|:.||:|||||||.||||||:|||:||.
  Rat     1 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATV 65

  Fly    66 HANLNVLLDEGQKHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQR 130
            |:::|.:|:|||::||||||||.|||||||.|.|||||||||||||||||.|||.||:|||||||
  Rat    66 HSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQR 130

  Fly   131 KAIEAFSGEVKRLCHAEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFL 195
            .|||.|.|||:||||||:||||||||||:|||||||||||||||||||.|||||:|.|:||||||
  Rat   131 NAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFL 195

  Fly   196 KVMSDSHTLQESQNLSMFLATQNKIRDTVKDTLEKIVGYEDLLSDVVNICVHMFETKMYLTPEEK 260
            :.|:|..::|||||||||||..|||..:::..||.|.|||:||:|:||:||..:|.:|||||.||
  Rat   196 RKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEK 260

  Fly   261 HMLVKVMGFGLFLMDSDACNINKLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHF 325
            |||:|||||||:|||....||.|||.||:|.|.:||:.||.|:||||||||||....|||.|.|:
  Rat   261 HMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHY 325

  Fly   326 D--SSKWPLSSSNAISPQADLMVHLPQIREDHVKYISELARYTN-EVTT---TVKENPSDAENRI 384
            :  .|:|..:||:: |||.::...:.||||||:::|||||||:| ||.|   ..:...:|||.|.
  Rat   326 EENKSRWTCTSSSS-SPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRK 389

  Fly   385 TADLALRGLQLLSEWTSVVTELYSWKLLHPTDHHQNKECPVEAEEYERATRYNYTSEEKFALIEV 449
            ..||||:||||||:|::.|.|:|||||:||||.:.||:||..|||||||||||||:||||||:||
  Rat   390 LFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDNAEEYERATRYNYTTEEKFALVEV 454

  Fly   450 IAMIKGLQVLMARIETVLCEAIRRNIYSELQDFVQLSLREPLRKAVKNKKDLIRSIIMSVRETSA 514
            |||||||||||.|:|:|...|||..:|:.||||.|::||||||:|:|.||::|:|::.::|:|..
  Rat   455 IAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVC 519

  Fly   515 DWQKGYEPTDDPVAKGKKDPDGGFRIQVPRLNVGPSSTQLYMVRTMLESLIADKSGGKRTLRKDI 579
            ||:.|:||.:||..:|:|||..||.|:|||..||||||||||||||||||||||||.|:|||..:
  Rat   520 DWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSL 584

  Fly   580 DGNCLLQIDTFHKTSFYWSYLLNFSDTLQKCCDLSQLWYREFYLEMTMGRKVNKCLVRHQHNEEC 644
            :|..:|.|:.||:.||::::|:|||:|||:||||||||:|||:||:||||
  Rat   585 EGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGR--------------- 634

  Fly   645 KDLITMEKRIQFPIEMSMPWILTDHILQTKEPSMMEFVLYPLDLYNDSAYYALTVFRKQFLYDEV 709
                    |||||||||||||||||||:|||.||||:|||.||||||||:||||.|.|||||||:
  Rat   635 --------RIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTKFNKQFLYDEI 691

  Fly   710 EAEVNLCFDQFVYKLSEQIFAHYKQLAGSIFLDKRFRLECEVLGFNFQSYPRNNRYETLLKQRHV 774
            |||||||||||||||::||||:||.:|||:.||||.|.||:..|.... .|.:||||||||||||
  Rat   692 EAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIH-LPPSNRYETLLKQRHV 755

  Fly   775 QLLGRSIDLNKLITQRINANMHKSIELAISRFEGNDITGIVELEGLLEANRICHKLLSKYLALDN 839
            ||||||||||:|||||::|.|:||:||||.|||..|:|.:|||:||||.||:.|||||:||.||:
  Rat   756 QLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSVVELDGLLEINRMTHKLLSRYLTLDS 820

  Fly   840 FDGMVKEANHNVLAPYGRITLHVFVELNYDFLVNYCYNAATNRFIRTKVNLSSSQAIQREKPPQM 904
            ||.|.:||||||.|||||||||||.|||||||.|||||.:||||:||.  |..||..||:|.|..
  Rat   821 FDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTV--LPFSQEFQRDKQPNA 883

  Fly   905 SHYYLWGSKQLNAAYSTQYGQYTGFVGSPHFHAMCRLLGYQGIAVVMDIILKDIVKPLIQGSLLQ 969
            ...||.|||.||.|||:.||.|..|||.|||..:|||||||||||||:.:|| :||.|:||::||
  Rat   884 QPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLK-VVKSLLQGTILQ 947

  Fly   970 FTKTLMIAMPKSCKLPRCEYGSPGVLSYYQAHLTDIVQYPDAKTELFQSFREFGNSIIFCLLIEQ 1034
            :.||||..|||.|:|||.||||||:|.::...|.|||:|.:.||..||:.||.||:::|||||||
  Rat   948 YVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAVLFCLLIEQ 1012

  Fly  1035 ALSQEEVCDLLHAALFQNIFPRPFCKENEKPEAKQKRLEAQFANLQIVSNVEKIGTAKQAMIARE 1099
            :||.||||||||||.||||.||...||.|:.:||.||||:::|.|.:|..:|::||.:|..||||
  Rat  1013 SLSLEEVCDLLHAAPFQNILPRVHVKEGERVDAKMKRLESKYAPLHLVPLIERLGTPQQIAIARE 1077

  Fly  1100 GDLLTRERLCCGLSIFEVILNRVKSYLDDPVWCGPPPANGIIHVDECSEFHRLWSALQFVYCIPV 1164
            |||||:||||||||:|||||.|::::||||:|.||.|:||::|||||.||||||||:||||||||
  Rat  1078 GDLLTKERLCCGLSMFEVILTRIRTFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPV 1142

  Fly  1165 RGTEYTIEELFGEGLNWAGCVMIVLLGQQRRFEALDFCYHILRVQRVDGKDEDVKGIQLKRMVDR 1229
            ...|:|:|:.||:||:||||::||||||||||..||||||:|:||:.|||||.:|.:.||:||:|
  Rat  1143 GTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVER 1207

  Fly  1230 IRRFQVLNSQIFSILNKYLKGGDGEGSNVEHVRCFPPPQHPSVISS 1275
            ||:||:||.:|.:||:||||.||||.:.|||||||.||.|.|:.||
  Rat  1208 IRKFQILNDEIITILDKYLKSGDGESTPVEHVRCFQPPIHQSLASS 1253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sra-1	NP_650447.1	DUF1394	89..>267	CDD:399855	133/177 (75%)
		FragX_IP	386..1244	CDD:399175	560/857 (65%)
Cyfip1	NP_001100987.1	FragX_IP	389..1222	CDD:399175	560/859 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341521
Domainoid	1	1.000	1163	1.000	Domainoid score	I13
eggNOG	1	0.900	-	-		E1_KOG3534
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1714	1.000	Inparanoid score	I65
OMA	1	1.010	-	-		QHG54601
OrthoDB	1	1.010	-	-		D108507at2759
OrthoFinder	1	1.000	-	-		FOG0003030
OrthoInspector	1	1.000	-	-		oto96618
orthoMCL	1	0.900	-	-		OOG6_102235
Panther	1	1.100	-	-	LDO	PTHR12195
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2020
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770