Protein Alignment Cyfip and Cyfip1

DIOPT Version :10

• Sequence 1: NP_650447.1
• Gene: Cyfip / 41861
• FlyBaseID: FBgn0038320
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: XP_063118405.1
• Gene: Cyfip1 / 308666
• RGDID: 1310332
• Length: 1260
• Species: Rattus norvegicus
• Alignment Length: 1281
• Identity: 839/1281 - (65%)
• Similarity: 1034/1281 - (80%)
• Gaps: 34/1281 - (2%)

  Fly     1 MTEKITLADALSNVEVLDELSLPDEQPCIEAQPCSIIYKANFDTNFEDRNGFVTGIAKYIEEATT 65
            |..::||.||||||::|:||.|||:|||||..|.|::|:.||:|||||||.||||||:|||:||.
  Rat     8 MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATV 72

  Fly    66 HANLNVLLDEGQKHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQR 130
            |:::|.:|:|||::||||||||.|||||||.|.|||||||||||||||||.|||.||:|||||||
  Rat    73 HSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQR 137

  Fly   131 KAIEAFSGEVKRLCHAEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFL 195
            .|||.|.|||:||||||:||||||||||:|||||||||||||||||||.|||||:|.|:||||||
  Rat   138 NAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFL 202

  Fly   196 KVMSDSHTLQESQNLSMFLATQNKIRDTVKDTLEKIVGYEDLLSDVVNICVHMFETKMYLTPEEK 260
            :.|:|..::|||||||||||..|||..:::..||.|.|||:||:|:||:||..:|.:|||||.||
  Rat   203 RKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEK 267

  Fly   261 HMLVKVMGFGLFLMDSDACNINKLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHF 325
            |||:|||||||:|||....||.|||.||:|.|.:||:.||.|:||||||||||....|||.|.|:
  Rat   268 HMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHY 332

  Fly   326 D--SSKWPLSSSNAISPQADLMVHLPQIREDHVKYISELARYTN-EVTT---TVKENPSDAENRI 384
            :  .|:|..:||:: |||.::...:.||||||:::|||||||:| ||.|   ..:...:|||.|.
  Rat   333 EENKSRWTCTSSSS-SPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRK 396

  Fly   385 TADLALRGLQLLSEWTSVVTELYSWKLLHPTDHHQNKECPVEAEEYERATRYNYTSEEKFALIEV 449
            ..||||:||||||:|::.|.|:|||||:||||.:.||:||..|||||||||||||:||||||:||
  Rat   397 LFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDNAEEYERATRYNYTTEEKFALVEV 461

  Fly   450 IAMIKGLQVLMARIETVLCEAIRRNIYSELQDFVQLSLREPLRKAVKNKKDLIRSIIMSVRETSA 514
            |||||||||||.|:|:|...|||..:|:.||||.|::||||||:|:|.||::|:|::.::|:|..
  Rat   462 IAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVC 526

  Fly   515 DWQKGYEPTDDPVAKGKKDPDGGFRIQVPRLNVGPSSTQLYMVRTMLESLIADKSGGKRTLRKDI 579
            ||:.|:||.:||..:|:|||..||.|:|||..||||||||||||||||||||||||.|:|||..:
  Rat   527 DWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSL 591

  Fly   580 DGNCLLQIDTFHKTSFYWSYLLNFSDTLQKCCDLSQLWYREFYLEMTMGRKVNKCLVRHQHNEEC 644
            :|..:|.|:.||:.||::::|:|||:|||:||||||||:|||:||:||||
  Rat   592 EGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGR--------------- 641

  Fly   645 KDLITMEKRIQFPIEMSMPWILTDHILQTKEPSMMEFVLYPLDLYNDSAYYALTVFRKQFLYDEV 709
                    |||||||||||||||||||:|||.||||:|||.||||||||:||||.|.|||||||:
  Rat   642 --------RIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTKFNKQFLYDEI 698

  Fly   710 EAEVNLCFDQFVYKLSEQIFAHYKQLAGSIFLDKRFRLECEVLGFNFQSYPRNNRYETLLKQRHV 774
            |||||||||||||||::||||:||.:|||:.||||.|.||:..|.... .|.:||||||||||||
  Rat   699 EAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIH-LPPSNRYETLLKQRHV 762

  Fly   775 QLLGRSIDLNKLITQRINANMHKSIELAISRFEGNDITGIVELEGLLEANRICHKLLSKYLALDN 839
            ||||||||||:|||||::|.|:||:||||.|||..|:|.:|||:||||.||:.|||||:||.||:
  Rat   763 QLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSVVELDGLLEINRMTHKLLSRYLTLDS 827

  Fly   840 FDGMVKEANHNVLAPYGRITLHVFVELNYDFLVNYCYNAATNRFIRTKVNLSSSQAIQREKPPQM 904
            ||.|.:||||||.|||||||||||.|||||||.|||||.:||||:||.  |..||..||:|.|..
  Rat   828 FDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTV--LPFSQEFQRDKQPNA 890

  Fly   905 SHYYLWGSKQLNAAYSTQYGQYTGFVGSPHFHAMCRLLGYQGIAVVMDIILKDIVKPLIQGSLLQ 969
            ...||.|||.||.|||:.||.|..|||.|||..:|||||||||||||:.:|| :||.|:||::||
  Rat   891 QPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLK-VVKSLLQGTILQ 954

  Fly   970 FTKTLMIAMPKSCKLPRCEYGSPGVLSYYQAHLTDIVQYPDAKTELFQSFREFGNSIIFCLLIEQ 1034
            :.||||..|||.|:|||.||||||:|.::...|.|||:|.:.||..||:.||.||:::|||||||
  Rat   955 YVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAVLFCLLIEQ 1019

  Fly  1035 ALSQEEVCDLLHAALFQNIFPRPFCKENEKPEAKQKRLEAQFANLQIVSNVEKIGTAKQAMIARE 1099
            :||.||||||||||.||||.||...||.|:.:||.||||:::|.|.:|..:|::||.:|..||||
  Rat  1020 SLSLEEVCDLLHAAPFQNILPRVHVKEGERVDAKMKRLESKYAPLHLVPLIERLGTPQQIAIARE 1084

  Fly  1100 GDLLTRERLCCGLSIFEVILNRVKSYLDDPVWCGPPPANGIIHVDECSEFHRLWSALQFVYCIPV 1164
            |||||:||||||||:|||||.|::::||||:|.||.|:||::|||||.||||||||:||||||||
  Rat  1085 GDLLTKERLCCGLSMFEVILTRIRTFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPV 1149

  Fly  1165 RGTEYTIEELFGEGLNWAGCVMIVLLGQQRRFEALDFCYHILRVQRVDGKDEDVKGIQLKRMVDR 1229
            ...|:|:|:.||:||:||||::||||||||||..||||||:|:||:.|||||.:|.:.||:||:|
  Rat  1150 GTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVER 1214

  Fly  1230 IRRFQVLNSQIFSILNKYLKGGDGEGSNVEHVRCFPPPQHPSVISS 1275
            ||:||:||.:|.:||:||||.||||.:.|||||||.||.|.|:.||
  Rat  1215 IRKFQILNDEIITILDKYLKSGDGESTPVEHVRCFQPPIHQSLASS 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyfip	NP_650447.1	CYRIA-B_Rac1-bd	89..>267	CDD:462106	133/177 (75%)
		FragX_IP	386..1244	CDD:461799	560/857 (65%)
Cyfip1	XP_063118405.1	None