DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sra-1 and Cyfip2

DIOPT Version :9

Sequence 1:	NP_650447.1	Gene:	Sra-1 / 41861	FlyBaseID:	FBgn0038320	Length:	1291	Species:	Drosophila melanogaster
Sequence 2:	NP_001100466.1	Gene:	Cyfip2 / 303073	RGDID:	1305048	Length:	593	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	377/615 - (61%)
Similarity:	473/615 - (76%)	Gaps:	25/615 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 SMPWILTDHILQTKEPSMMEFVLYPLDLYNDSAYYALTVFRKQFLYDEVEAEVNLCFDQFVYKLS 725
            |.|||.|     |..|:|.          :.|:..:..:.|.:      :.:||||||||||||:
  Rat     3 STPWICT-----TTAPTMR----------SPSSKSSSCMTRSK------QRQVNLCFDQFVYKLA 46

  Fly   726 EQIFAHYKQLAGSIFLDKRFRLECEVLGFNFQSYPRNNRYETLLKQRHVQLLGRSIDLNKLITQR 790
            :||||:||.:|||:.||||||.||:..|. ...||.:||||||||||||||||||||||:|||||
  Rat    47 DQIFAYYKAMAGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQR 110

  Fly   791 INANMHKSIELAISRFEGNDITGIVELEGLLEANRICHKLLSKYLALDNFDGMVKEANHNVLAPY 855
            |:|.|:||::.||||||..|:|.|||||.|||.||:.|:||.|::.||:||.|.:||||||.|||
  Rat   111 ISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPY 175

  Fly   856 GRITLHVFVELNYDFLVNYCYNAATNRFIRTKVNLSSSQAIQREKPPQMSHYYLWGSKQLNAAYS 920
            ||||||||.|||:|||.|||||.:||||:||.:..  :|..||:||..:..|||:|||.||.|||
  Rat   176 GRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPF--TQEPQRDKPANVQPYYLYGSKPLNIAYS 238

  Fly   921 TQYGQYTGFVGSPHFHAMCRLLGYQGIAVVMDIILKDIVKPLIQGSLLQFTKTLMIAMPKSCKLP 985
            ..|..|..|||.|||..:|||||||||||||:.:|| |||.|:||::||:.|||:..|||.|:||
  Rat   239 HIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLK-IVKSLLQGTILQYVKTLIEVMPKICRLP 302

  Fly   986 RCEYGSPGVLSYYQAHLTDIVQYPDAKTELFQSFREFGNSIIFCLLIEQALSQEEVCDLLHAALF 1050
            |.||||||:|.::...|.||::|.:.||::|||.||.||:|:|||||||||||||||||||||.|
  Rat   303 RHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPF 367

  Fly  1051 QNIFPRPFCKENEKPEAKQKRLEAQFANLQIVSNVEKIGTAKQAMIAREGDLLTRERLCCGLSIF 1115
            |||.||.:.||.|:.|.:.|||||::|.|.:|..:|::||.:|..|||||||||:||||||||:|
  Rat   368 QNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMF 432

  Fly  1116 EVILNRVKSYLDDPVWCGPPPANGIIHVDECSEFHRLWSALQFVYCIPVRGTEYTIEELFGEGLN 1180
            ||||.|::|||.||:|.||||.||::|||||.||||||||:||||||||...|:|.|:.||:|||
  Rat   433 EVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLN 497

  Fly  1181 WAGCVMIVLLGQQRRFEALDFCYHILRVQRVDGKDEDVKGIQLKRMVDRIRRFQVLNSQIFSILN 1245
            ||||.::|||||||||:..|||||:|:|||.|||||.:|.:.||:|.||||::|:||:::|:|||
  Rat   498 WAGCSIVVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILN 562

  Fly  1246 KYLKGGDGEGSNVEHVRCFPPPQHPSVISS 1275
            ||:|..:.:.|.|||||||.||.|.|:.::
  Rat   563 KYMKSVETDSSTVEHVRCFQPPIHQSLATT 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sra-1	NP_650447.1	DUF1394	89..>267	CDD:399855
Sra-1	NP_650447.1	FragX_IP	386..1244	CDD:399175	359/582 (62%)
Cyfip2	NP_001100466.1	FragX_IP	<34..561	CDD:283615	349/530 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341520
Domainoid	1	1.000	1163	1.000	Domainoid score	I13
eggNOG	1	0.900	-	-		E1_KOG3534
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54601
OrthoDB	1	1.010	-	-		D108507at2759
OrthoFinder	1	1.000	-	-		FOG0003030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102235
Panther	1	1.100	-	-	O	PTHR12195
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2020
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.760