Protein Alignment Sra-1 and gex-2

DIOPT Version :9

• Sequence 1: NP_650447.1
• Gene: Sra-1 / 41861
• FlyBaseID: FBgn0038320
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: NP_499949.2
• Gene: gex-2 / 176885
• WormBaseID: WBGene00001579
• Length: 1262
• Species: Caenorhabditis elegans
• Alignment Length: 1295
• Identity: 668/1295 - (51%)
• Similarity: 890/1295 - (68%)
• Gaps: 48/1295 - (3%)

  Fly     1 MTEKITLADALSNVEVLDELSLPDEQPCIEAQPCSIIYKANFDTNFEDRNGFVTGIAKYIEEATT 65
            |...:|:.||:|||.:||.|::||:.|.|||:...::|::|||||||||:.||||||||.||||.
 Worm     1 MNANVTVDDAISNVNLLDTLAIPDDLPDIEARALPLLYRSNFDTNFEDRSAFVTGIAKYSEEATR 65

  Fly    66 HANLNVLLDEGQKHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQR 130
            ||..|.:|.||.:||..:|||||||||:|..|||:||||.||.|..||||.|||:||.:||.|..
 Worm    66 HAQFNDMLSEGLQHAANMYTWRCCSRAVPMAKSNDQPNRTEINEMVVEVLKPEVSKLGSFMRFTL 130

  Fly   131 KAIEAFSGEVKRLCHAEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFL 195
            .||:.|..||:||||:|||:||||||||||||:|||||||||||||||:|:|||:||:|||:|||
 Worm   131 TAIQRFCEEVRRLCHSEKRRDFVSEAYLLTLGRFINMFAVLDELKNMKASIKNDFSTFRRASQFL 195

  Fly   196 KVMSDSHTLQESQNLSMFLATQNKIRDTVKDTLEKIVGYEDLLSDVVNICVHMFETKMYLTPEEK 260
            ..|||:..:.:.|||||||||||||:|.:|..::.|.|||:||.||||||.||:|.::||:|.||
 Worm   196 TAMSDTQAVHDMQNLSMFLATQNKIKDDLKLQMKTIEGYEELLCDVVNICAHMYEHQLYLSPNEK 260

  Fly   261 HMLVKVMGFGLFLMDSDACNINKLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHF 325
            ||.|||:.|.|||||.||.|:.||||||::.:.|:|:|||.||||||:|||||.||.:::||.|:
 Worm   261 HMFVKVIAFSLFLMDGDAANVAKLDQKKRLSISRLDKIFKTLEVVPLYGDMQIQPFAFVRRSSHY 325

  Fly   326 DSSKWPLSSSNAISPQADLMVHLPQIREDHVKYISELARYTNEVTTTVKENP-SDAENRITADLA 389
            :.||||||...:.....:::..:..||.||..|:::.|:..|||  .:.:.| :|:|||....||
 Worm   326 EPSKWPLSDKESDRCHVNIVEKVQSIRSDHESYVTQFAKINNEV--AICDRPGNDSENREITSLA 388

  Fly   390 LRGLQLLSEWTSVVTELYSWKLLHPTDHHQNKECPVEAEEYERATRYNYTSEEKFALIEVIAMIK 454
            |.|:|||.:|:..|.|..|||||:||:...|:|||..||||||||||||:..||.|||::|||||
 Worm   389 LSGIQLLCQWSCAVVETISWKLLNPTNPKDNRECPENAEEYERATRYNYSPAEKTALIQIIAMIK 453

  Fly   455 GLQVLMARIETVLCEAIRRNIYSELQDFVQLSLREPLRKAVKNKKDLIRSIIMSVRETSADWQKG 519
            |||.::.:.|:.:..:.|:.:|.|||.|:..::.|||:||||:||||:.||:.||:::.:|  .|
 Worm   454 GLQSMLGKTESDMSNSTRKCVYVELQAFIHHTINEPLQKAVKHKKDLLASILQSVKDSISD--AG 516

  Fly   520 YEPTDDPVAKGKKD---PDG------GFRIQVPRLNVGPSSTQLYMVRTMLESLIADK-SGGKRT 574
            .|.......||||.   |.|      ...|::||....|.||||||.||.|||||:|| .|||:.
 Worm   517 NELNRMTDVKGKKKSSAPKGDSANSSSSDIRIPRRTAAPGSTQLYMARTQLESLISDKLCGGKKI 581

  Fly   575 LRKDIDGNCLLQIDTFHKTSFYWSYLLNFSDTLQKCCDLSQLWYREFYLEMTMGRKVNKCLVRHQ 639
            |||::|...:.:|..|.:.|.:|..|...||::.:..:|||||:||||||||||
 Worm   582 LRKELDSKTIEKISVFLRKSAHWPALFRLSDSMTEAGELSQLWFREFYLEMTMG----------- 635

  Fly   640 HNEECKDLITMEKRIQFPIEMSMPWILTDHILQTKEPSMMEFVLYPLDLYNDSAYYALTVFRKQF 704
                        :||||||||||||||||:||...|||::|..||.||||||:|.|:|..|.|||
 Worm   636 ------------QRIQFPIEMSMPWILTDYILSCNEPSLIESALYQLDLYNDAAQYSLFNFNKQF 688

  Fly   705 LYDEVEAEVNLCFDQFVYKLSEQIFAHYKQLAGSIFLDKRFRLECEVLGFNFQSYPRNNRYETLL 769
            ||||||||||||||||||||||.:|.||||||..:.|||||:.|....|...:| |...|:|:||
 Worm   689 LYDEVEAEVNLCFDQFVYKLSEMVFTHYKQLASCMLLDKRFKAEILRSGTMIRS-PSAARFESLL 752

  Fly   770 KQRHVQLLGRSIDLNKLITQRINANMHKSIELAISRFEGNDITGIVELEGLLEANRICHKLLSKY 834
            :||||||||||:|||::::||:|..:.|:::.||.:||...::.||||:.|::.||:||.|||..
 Worm   753 QQRHVQLLGRSVDLNRVVSQRVNMALLKALDAAIWKFESEPLSSIVELDMLIDTNRLCHTLLSDV 817

  Fly   835 L-ALDNFDGMVKEANHNVLAPYGRITLHVFVELNYDFLVNYCYNAATNRFIRTKVNLSSSQAIQR 898
            | ::..||.:.:||||.|.:|:||||||||.||||||:.|:.||.:|:||:|.:.....:.|  |
 Worm   818 LHSIAPFDDLFQEANHAVNSPHGRITLHVFWELNYDFVPNFVYNGSTHRFVRARHVFRKTPA--R 880

  Fly   899 EKPPQMSHYYLWGSKQLNAAYSTQYGQYTGFVGSPHFHAMCRLLGYQGIAVVMDIILKDIVKPLI 963
            |||||:...|.||||.|.||:......|:..:|:.|..|:.|||.||||||::|.:|| :...|:
 Worm   881 EKPPQVGQVYYWGSKSLMAAFMNICNAYSQCIGTQHLKAITRLLHYQGIAVILDELLK-MTNRLL 944

  Fly   964 QGSLLQFTKTLMIAMPKSCKLPRCEYGSPGVLSYYQAHLTDIVQYPDAKTELFQSFREFGNSIIF 1028
            ...:.:..:.:...|||.|||||.:|||..:|.||..||..:.:||:.|:|..|..||.||.|:|
 Worm   945 NDKIRRHVRNVFNMMPKVCKLPRSDYGSNALLQYYVHHLEAVGKYPELKSEFCQDLRELGNMIVF 1009

  Fly  1029 CLLIEQALSQEEVCDLLHAALFQNIFPRPFCKENEKPEAKQKRLEAQFANLQIVSNVEKIGTAK- 1092
            |..:|.||.|||..||..||.:....|:|..:..::...:..:||.:::.:.:...::||....
 Worm  1010 CQQLEVALGQEEAHDLFLAAAYTGTVPQPPARNAQEQMKQLAKLEDKYSRIHLTEIIDKISPDDG 1074

  Fly  1093 QAMIAREGDLLTRERLCCGLSIFEVILNRVKSYL-DDPVWCGPPPANGIIHVDECSEFHRLWSAL 1156
            ||.||::.:|:|:|||||||:.||..|.|:|..| .|.:|.|..|.||:..:|||.|::|::|||
 Worm  1075 QAAIAKDAELMTKERLCCGLNAFENFLVRIKQMLAADDIWTGGYPTNGVFWIDECVEWYRVYSAL 1139

  Fly  1157 QFVYCIPVR-GTEYTIEELFGEGLNWAGCVMIVLLGQQRRFEALDFCYHILRVQRVDGKDEDVKG 1220
            ||..|.|.| ..|...|||||:.|.|.|..:|.||||.||||.||||||:.||.:.|||||.:.|
 Worm  1140 QFFLCQPTRDDNEVYAEELFGDSLQWGGLTLITLLGQHRRFEVLDFCYHLHRVNKADGKDEVISG 1204

  Fly  1221 IQLKRMVDRIRRFQVLNSQIFSILNKYLKGGDGEGSNVEHVRCFPPPQHPSVISSSSHYQ 1280
            |:|.:||:||||||:||:|||.||...|...:.:.:  |.||.|.||.||:..:.::..|
 Worm  1205 IRLAKMVERIRRFQLLNNQIFIILENQLNENNDDPN--ERVREFAPPVHPNYANHAARRQ 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sra-1	NP_650447.1	DUF1394	89..>267	CDD:399855	120/177 (68%)
		FragX_IP	386..1244	CDD:399175	428/871 (49%)
gex-2	NP_499949.2	DUF1394	71..>263	CDD:284554	127/191 (66%)
		FragX_IP	383..1228	CDD:283615	428/873 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159679
Domainoid	1	1.000	804	1.000	Domainoid score	I26
eggNOG	1	0.900	-	-		E1_KOG3534
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1281	1.000	Inparanoid score	I71
Isobase	1	0.950	-	0	Normalized mean entropy	S2358
OMA	1	1.010	-	-		QHG54601
OrthoDB	1	1.010	-	-		D108507at2759
OrthoFinder	1	1.000	-	-		FOG0003030
OrthoInspector	1	1.000	-	-		oto17504
orthoMCL	1	0.900	-	-		OOG6_102235
Panther	1	1.100	-	-	LDO	PTHR12195
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2470
SonicParanoid	1	1.000	-	-		X2020
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750