Protein Alignment Sra-1 and cyfip2

DIOPT Version :9

• Sequence 1: NP_650447.1
• Gene: Sra-1 / 41861
• FlyBaseID: FBgn0038320
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: NP_001103523.1
• Gene: cyfip2 / 100126215
• XenbaseID: XB-GENE-922699
• Length: 1253
• Species: Xenopus tropicalis
• Alignment Length: 1280
• Identity: 844/1280 - (65%)
• Similarity: 1026/1280 - (80%)
• Gaps: 33/1280 - (2%)

  Fly     1 MTEKITLADALSNVEVLDELSLPDEQPCIEAQPCSIIYKANFDTNFEDRNGFVTGIAKYIEEATT 65
            ||..:||.||||||::|:||.|||:|||||..|.||:|:|||||||||||.||||||:|||:||.
 Frog     1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATV 65

  Fly    66 HANLNVLLDEGQKHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQR 130
            |:::|.:|:|||::||||||||.|||||||.|.|||||||||||||||||.|||.||:.||||||
 Frog    66 HSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQR 130

  Fly   131 KAIEAFSGEVKRLCHAEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFL 195
            ||||.|..|||||||||:||||||||||||||||||||||||||||||.|||||:|.|:||||||
 Frog   131 KAIERFCNEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFL 195

  Fly   196 KVMSDSHTLQESQNLSMFLATQNKIRDTVKDTLEKIVGYEDLLSDVVNICVHMFETKMYLTPEEK 260
            :.|:|..::|||||||||||..|:|...:...||.|.|||:||:|:|||||..:|.||||||.||
 Frog   196 RKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEK 260

  Fly   261 HMLVKVMGFGLFLMDSDACNINKLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHF 325
            |||:|||||||:|||.:..||.|||.||:|.|.:||:.||.|:||||||||||....||:.|.|:
 Frog   261 HMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIETSAHY 325

  Fly   326 D--SSKWPLSSSNAISPQADLMVHLPQIREDHVKYISELARYTNEVTTT---VKENPSDAENRIT 385
            :  .|||..:.| :||||.::...:.|||:||:::|||||||:|....|   :....||.|.|..
 Frog   326 EENKSKWTCTQS-SISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYREL 389

  Fly   386 ADLALRGLQLLSEWTSVVTELYSWKLLHPTDHHQNKECPVEAEEYERATRYNYTSEEKFALIEVI 450
            .|||||||||||:|::.|.|:|||||:||||...||:||..|||||||||||||||||||.:|||
 Frog   390 FDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVI 454

  Fly   451 AMIKGLQVLMARIETVLCEAIRRNIYSELQDFVQLSLREPLRKAVKNKKDLIRSIIMSVRETSAD 515
            ||:|||||||.|:|:|..:|||..||:.||||.|.|||||||:||:.||:::.|::.::|:|..|
 Frog   455 AMVKGLQVLMGRMESVFNQAIRNTIYAALQDFAQSSLREPLRQAVRKKKNVLISVLQAIRKTVCD 519

  Fly   516 WQKGYEPTDDPVAKGKKDPDGGFRIQVPRLNVGPSSTQLYMVRTMLESLIADKSGGKRTLRKDID 580
            |:.|.||.:||..:|:|||.|||.|:|||..||||||||||||||||||||||||.|:|||..:|
 Frog   520 WEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLD 584

  Fly   581 GNCLLQIDTFHKTSFYWSYLLNFSDTLQKCCDLSQLWYREFYLEMTMGRKVNKCLVRHQHNEECK 645
            |..:..|:.|||.||::::|||||:.||:||||||||:|||:||:||||
 Frog   585 GPIVQAIEEFHKQSFFFTHLLNFSEALQQCCDLSQLWFREFFLELTMGR---------------- 633

  Fly   646 DLITMEKRIQFPIEMSMPWILTDHILQTKEPSMMEFVLYPLDLYNDSAYYALTVFRKQFLYDEVE 710
                   |||||||||||||||||||:||||||||:|||||||||||||||||.|:|||||||:|
 Frog   634 -------RIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIE 691

  Fly   711 AEVNLCFDQFVYKLSEQIFAHYKQLAGSIFLDKRFRLECEVLGFNFQSYPRNNRYETLLKQRHVQ 775
            |||||||||||||||:||||:||.::||:.||||||.||:..|. ...||.:|||||||||||||
 Frog   692 AEVNLCFDQFVYKLSDQIFAYYKAMSGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQ 755

  Fly   776 LLGRSIDLNKLITQRINANMHKSIELAISRFEGNDITGIVELEGLLEANRICHKLLSKYLALDNF 840
            |||||||||:||||||:|.|:||::.||||||..|:|.|||||.||:.||:.|:||||:|.||:|
 Frog   756 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLDINRLTHRLLSKHLTLDSF 820

  Fly   841 DGMVKEANHNVLAPYGRITLHVFVELNYDFLVNYCYNAATNRFIRTKVNLSSSQAIQREKPPQMS 905
            |.|.:||||||.|||||.|||||.|||:|||.|||||.:||||:||.:..  :|..||:||..:.
 Frog   821 DAMFREANHNVSAPYGRNTLHVFWELNFDFLPNYCYNGSTNRFVRTAIPF--TQEPQRDKPANVQ 883

  Fly   906 HYYLWGSKQLNAAYSTQYGQYTGFVGSPHFHAMCRLLGYQGIAVVMDIILKDIVKPLIQGSLLQF 970
            .|||:|||.||.|||..|..|..|||.|||..:|||||||||||||:.:|| |||.|:||::||:
 Frog   884 PYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLK-IVKSLLQGTILQY 947

  Fly   971 TKTLMIAMPKSCKLPRCEYGSPGVLSYYQAHLTDIVQYPDAKTELFQSFREFGNSIIFCLLIEQA 1035
            .|||:..|||.|:|||.||||||:|.::...|.||::|.:.||::|||.||.||:|:||||||||
 Frog   948 VKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQA 1012

  Fly  1036 LSQEEVCDLLHAALFQNIFPRPFCKENEKPEAKQKRLEAQFANLQIVSNVEKIGTAKQAMIAREG 1100
            |||||||||||||.||||.||.:.||.|:.|.:.|||||::|.|.:|..:|::||.:|..|||||
 Frog  1013 LSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREG 1077

  Fly  1101 DLLTRERLCCGLSIFEVILNRVKSYLDDPVWCGPPPANGIIHVDECSEFHRLWSALQFVYCIPVR 1165
            ||||:||||||||:|||||.|::|||.||:|.||||.||::|||||.|.||||||:||||||||.
 Frog  1078 DLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVELHRLWSAMQFVYCIPVG 1142

  Fly  1166 GTEYTIEELFGEGLNWAGCVMIVLLGQQRRFEALDFCYHILRVQRVDGKDEDVKGIQLKRMVDRI 1230
            ..|:|.|:.||:|||||||.:||||||||||:..|||||:|:|||.|||||.:|.:.||:|.|||
 Frog  1143 TNEFTAEQCFGDGLNWAGCAIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRI 1207

  Fly  1231 RRFQVLNSQIFSILNKYLKGGDGEGSNVEHVRCFPPPQHPSVISS 1275
            |::|:||::||::||||:|..:.:.|.|||||||.||.|.|:.::
 Frog  1208 RKYQILNNEIFAVLNKYMKSVESDSSTVEHVRCFQPPIHQSLATT 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sra-1	NP_650447.1	DUF1394	89..>267	CDD:399855	135/177 (76%)
		FragX_IP	386..1244	CDD:399175	568/857 (66%)
cyfip2	NP_001103523.1	DUF1394	65..>267	CDD:284554	149/201 (74%)
		FragX_IP	388..1221	CDD:283615	568/859 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1154	1.000	Domainoid score	I15
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7936
Inparanoid	1	1.050	1708	1.000	Inparanoid score	I70
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D108507at2759
OrthoFinder	1	1.000	-	-		FOG0003030
OrthoInspector	1	1.000	-	-		otm48242
Panther	1	1.100	-	-	O	PTHR12195
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2020
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160