DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sra-1 and cyfip2

DIOPT Version :9

Sequence 1:	NP_650447.1	Gene:	Sra-1 / 41861	FlyBaseID:	FBgn0038320	Length:	1291	Species:	Drosophila melanogaster
Sequence 2:	NP_001091056.1	Gene:	cyfip2 / 100002872	ZFINID:	ZDB-GENE-080724-2	Length:	1253	Species:	Danio rerio

Alignment Length:	1281	Identity:	846/1281 - (66%)
Similarity:	1026/1281 - (80%)	Gaps:	35/1281 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEKITLADALSNVEVLDELSLPDEQPCIEAQPCSIIYKANFDTNFEDRNGFVTGIAKYIEEATT 65
            ||..:||.||||||::|:||.|||:|||||..|.||:|:|||||||||||.||||||:|||:||.
Zfish     1 MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATV 65

  Fly    66 HANLNVLLDEGQKHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQR 130
            |:::|.:|:||.::||||||||.|||||||.|.|||||||||||||||||.|||.||:.||||||
Zfish    66 HSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQR 130

  Fly   131 KAIEAFSGEVKRLCHAEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFL 195
            ||||.|..|||||||||:||||||||||||||||||||||||||||||.|||||:|.|:||||||
Zfish   131 KAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFL 195

  Fly   196 KVMSDSHTLQESQNLSMFLATQNKIRDTVKDTLEKIVGYEDLLSDVVNICVHMFETKMYLTPEEK 260
            :.|:|..::|||||||||||..|:|...:...||.|.|||:||:|:|||||..:|.||||||.||
Zfish   196 RKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEK 260

  Fly   261 HMLVKVMGFGLFLMDSDACNINKLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHF 325
            |||:|||||||:|||.:..||.|||.||:|.|.:||:.|| |:||||||||||....||:.|.|:
Zfish   261 HMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFK-LQVVPLFGDMQIELSRYIETSAHY 324

  Fly   326 D--SSKWPLSSSNAISPQADLMVHLPQIREDHVKYISELARYTNEVTTT---VKENPSDAENRIT 385
            :  .|||..:.| :||||.:|...:.||||||:::|||||||:|....|   :....||.|.|..
Zfish   325 EENKSKWTCTQS-SISPQYNLCEQMVQIREDHIRFISELARYSNSEVVTGSGLDSQKSDEEYREL 388

  Fly   386 ADLALRGLQLLSEWTSVVTELYSWKLLHPTDHHQNKECPVEAEEYERATRYNYTSEEKFALIEVI 450
            .|||||||||||:|::.|.|:|||||:||||...||:||..||||||||||||||||||||:|||
Zfish   389 FDLALRGLQLLSKWSTHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFALVEVI 453

  Fly   451 AMIKGLQVLMARIETVLCEAIRRNIYSELQDFVQLSLREPLRKAVKNKKDLIRSIIMSVRETSAD 515
            ||||||||||.|:|:|..:|||..|||.||||.|::||||||:||:.||:::.|::.::|:|..|
Zfish   454 AMIKGLQVLMGRMESVFNQAIRHTIYSALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICD 518

  Fly   516 WQKGYEPTDDPVAKGKKDPDGGFRIQVPRLNVGPSSTQLYMVRTMLESLIADKSGGKRTLRKDID 580
            |:...||.:||..:|:|||.|||.|:|||..||||||||||||||||||||||||.|:|||..:|
Zfish   519 WEGAREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLD 583

  Fly   581 GNCLLQIDTFHKTSFYWSYLLNFSDTLQKCCDLSQLWYREFYLEMTMGRKVNKCLVRHQHNEECK 645
            |..:..|:.|||.||::::|||||:.||:||||||||:|||:||:||||
Zfish   584 GPIVQAIEDFHKQSFFFTHLLNFSEALQQCCDLSQLWFREFFLELTMGR---------------- 632

  Fly   646 DLITMEKRIQFPIEMSMPWILTDHILQTKEPSMMEFVLYPLDLYNDSAYYALTVFRKQFLYDEVE 710
                   |||||||||||||||||||:||||||||:|||||||||||.|||||.|:|||||||:|
Zfish   633 -------RIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSGYYALTKFKKQFLYDEIE 690

  Fly   711 AEVNLCFDQFVYKLSEQIFAHYKQLAGSIFLDKRFRLECEVLGFNFQSYPRNNRYETLLKQRHVQ 775
            ||||||||||||||::||||:||.:|||:.||||||.||:..|. ...||.:|||||||||||||
Zfish   691 AEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQ 754

  Fly   776 LLGRSIDLNKLITQRINANMHKSIELAISRFEGNDITGIVELEGLLEANRICHKLLSKYLALDNF 840
            |||||||||:||||||:|.|:||::.||||||..|:|.|||||.|||.||:.|:||||::.||:|
Zfish   755 LLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLSKHMTLDSF 819

  Fly   841 DGMVKEANHNVLAPYGRITLHVFVELNYDFLVNYCYNAATNRFIRTKVNLSSSQAIQREKPPQMS 905
            |.|.:||||||.|||||||||||.|||:|||.|||||.:||||:||.:..  :|..||:||..:.
Zfish   820 DAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPF--TQEPQRDKPANVQ 882

  Fly   906 HYYLWGSKQLNAAYSTQYGQYTGFVGSPHFHAMCRLLGYQGIAVVMDIILKDIVKPLIQGSLLQF 970
            .|||:|||.||.|||..|..|..|||.|||..:|||||||||||||:.:|| |||.|:||::||:
Zfish   883 PYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLK-IVKSLLQGTILQY 946

  Fly   971 TKTLMIAMPKSCKLPRCEYGSPGVLSYYQAHLTDIVQYPDAKTELFQSFREFGNSIIFCLLIEQA 1035
            .|||:..|||.|:|||.||||||:|.::...|.||::|.:.||::|||.||.||:::||||||||
Zfish   947 VKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAVLFCLLIEQA 1011

  Fly  1036 L-SQEEVCDLLHAALFQNIFPRPFCKENEKPEAKQKRLEAQFANLQIVSNVEKIGTAKQAMIARE 1099
            | ||||||||||||.||||.||.:.||.|:.|.:.|||||::|.|.:|..:|::||.:|..||||
Zfish  1012 LVSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIARE 1076

  Fly  1100 GDLLTRERLCCGLSIFEVILNRVKSYLDDPVWCGPPPANGIIHVDECSEFHRLWSALQFVYCIPV 1164
            |||||:||||||||:|||||.|::|:|.|.||.||||.||::|||||.||||||||:||||||||
Zfish  1077 GDLLTKERLCCGLSMFEVILTRIRSFLQDNVWRGPPPTNGVMHVDECMEFHRLWSAMQFVYCIPV 1141

  Fly  1165 RGTEYTIEELFGEGLNWAGCVMIVLLGQQRRFEALDFCYHILRVQRVDGKDEDVKGIQLKRMVDR 1229
            ...|:|.|:.||:|||||||.:||||||||||:..|||||:|:|||.|||||.:|.:.||:|.||
Zfish  1142 GTHEFTAEQCFGDGLNWAGCAIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADR 1206

  Fly  1230 IRRFQVLNSQIFSILNKYLKGGDGEGSNVEHVRCFPPPQHPSVISS 1275
            ||::|:||::||:|||||:|..:.:.|.|||||||.||.|.|:.::
Zfish  1207 IRKYQILNNEIFAILNKYMKAVETDSSTVEHVRCFQPPIHQSLATT 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sra-1	NP_650447.1	DUF1394	89..>267	CDD:399855	135/177 (76%)
Sra-1	NP_650447.1	FragX_IP	386..1244	CDD:399175	568/858 (66%)
cyfip2	NP_001091056.1	DUF1394	65..>267	CDD:284554	148/201 (74%)
cyfip2	NP_001091056.1	FragX_IP	387..1221	CDD:283615	568/860 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581522
Domainoid	1	1.000	1156	1.000	Domainoid score	I15
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7936
Inparanoid	1	1.050	1691	1.000	Inparanoid score	I71
OMA	1	1.010	-	-		QHG54601
OrthoDB	1	1.010	-	-		D108507at2759
OrthoFinder	1	1.000	-	-		FOG0003030
OrthoInspector	1	1.000	-	-		otm24482
orthoMCL	1	0.900	-	-		OOG6_102235
Panther	1	1.100	-	-	O	PTHR12195
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2470
SonicParanoid	1	1.000	-	-		X2020
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940