DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and gzma

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_001335166.1	Gene:	gzma / 795070	ZFINID:	ZDB-GENE-091204-156	Length:	257	Species:	Danio rerio

Alignment Length:	285	Identity:	76/285 - (26%)
Similarity:	116/285 - (40%)	Gaps:	71/285 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 CGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHCVNGKALPTDW 184
            |.::   .|.||...| ....||..|     |..:.|.|||.||...:|:||:||..........
Zfish    23 CSDV---SIVGGKDVK-KALSWMVSI-----QVNQNHKCGGILIHKEWVLTAAHCKEDSYSSVTV 78

  Fly   185 RLSGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQVNDIALLRLAQQ 249
            .:..:.|.              :|.:..|..:.::|....         .|.:.:||.|:||:::
Zfish    79 LIGSLSLS--------------KGSQRIAIHNYEIPETFN---------KKTKKDDIMLIRLSKK 120

  Fly   250 VEYTDFVRPICLP---LDVNLRSATFDGITMDVAGWGKTEQLSASNLKLKAAVEGFRMDE----- 306
            |:    .:|..:|   .||.      .|....|.|||.|:      .|.|.|.:..:|.|
Zfish   121 VK----AKPYKIPKKEKDVQ------PGTKCVVRGWGTTD------YKGKQASDKLQMLEVLVVD 169

  Fly   307 ---CQNVYSSQDILLEDTQMCAGG-KEGVDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGPTPC 367
               |...|:...::.:| .:|||. ::...:|.||||||| ..:.|       |.||:| |...|
Zfish   170 RVQCNRYYNRNPVITKD-MLCAGNTQQHRGTCLGDSGGPL-ECEKN-------LVGVLS-GSHGC 224

  Fly   368 GLAGWPGVYTLVGK-YVDWIQNTIE 391
            |....|.||||:.| ::.||...::
Zfish   225 GDPKKPTVYTLLSKRHITWINKILK 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	73/271 (27%)
		Tryp_SPc	128..389	CDD:238113	75/273 (27%)
gzma	XP_001335166.1	Tryp_SPc	28..247	CDD:238113	75/273 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930