DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and TPSAB1

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_003285.2	Gene:	TPSAB1 / 7177	HGNCID:	12019	Length:	275	Species:	Homo sapiens

Alignment Length:	302	Identity:	93/302 - (30%)
Similarity:	131/302 - (43%)	Gaps:	76/302 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 PLPGQCGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKG-HHCGGSLISTRYVITASHCVNGK 178
            |.|||.  :....|.||.:....::||...:   :..|... |.||||||..::|:||:|||
Human    20 PAPGQA--LQRVGIVGGQEAPRSKWPWQVSL---RVHGPYWMHFCGGSLIHPQWVLTAAHCV--- 76

  Fly   179 ALPTDWRLSGVRLGEWDTNTNPDCEVDVRGMKDCA-------PPHLD-----VPVERTIPHPDYI 231
                                .||       :||.|       ..||.     :||.|.|.||.:.
Human    77 --------------------GPD-------VKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFY 114

  Fly   232 PASKNQVN-DIALLRLAQQVEYTDFVRPICLPLDVNLRSATF-DGITMDVAGWGKTEQLSASNLK 294
            .|   |:. |||||.|.:.|..:..|..:.||    ..|.|| .|:...|.|||..:  :...|.
Human   115 TA---QIGADIALLELEEPVNVSSHVHTVTLP----PASETFPPGMPCWVTGWGDVD--NDERLP 170

  Fly   295 LKAAVEGFRMDECQN----------VYSSQDI-LLEDTQMCAGGKEGVDSCRGDSGGPLIGLDTN 348
            ....::..::...:|          .|:..|: ::.|..:|||.... |||:|||||||:    .
Human   171 PPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRR-DSCQGDSGGPLV----C 230

  Fly   349 KVNTYYFLAGVVSFGPTPCGLAGWPGVYTLVGKYVDWIQNTI 390
            |||..:..|||||:| ..|.....||:||.|..|:|||.:.:
Human   231 KVNGTWLQAGVVSWG-EGCAQPNRPGIYTRVTYYLDWIHHYV 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	87/284 (31%)
		Tryp_SPc	128..389	CDD:238113	89/286 (31%)
TPSAB1	NP_003285.2	Tryp_SPc	31..268	CDD:238113	88/284 (31%)
TPSAB1	NP_003285.2	Tryp_SPc	31..267	CDD:214473	87/283 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152807
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840