Protein Alignment ea and TMPRSS2

DIOPT Version :10

• Sequence 1: NP_524362.2
• Gene: ea / 41858
• FlyBaseID: FBgn0000533
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_001128571.1
• Gene: TMPRSS2 / 7113
• HGNCID: 11876
• Length: 529
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 125/452 - (27%)
• Similarity: 181/452 - (40%)
• Gaps: 134/452 - (29%)

  Fly     2 LKPSIICLFLGILAKSSAGQFYFPNEAAQVPNYGRCITPNR---ERALCIHLED---CKYLYG-- 58
            |...::..|:|  :|.|       |...:..:.|.||.|:.   ..:.|...||   |..|||
Human   137 LAAGLLWKFMG--SKCS-------NSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN 192

  Fly    59 --LLTTTPLR---------DTDRLYLSRSQC---GYTN------------------------GKV 85
              |...:..|         |.:..| .|:.|   ||.|                        |.|
Human   193 FILQVYSSQRKSWHPVCQDDWNENY-GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNV 256

  Fly    86 LICCPDRYRESSSETTPPPKPNVTSNSLLPLPGQCG-NILS---NRIYGGMKTKIDEFPWMALIE 146
                 |.|::.........|..|:...:     .|| |:.|   :||.||.......:||...:.
Human   257 -----DIYKKLYHSDACSSKAVVSLRCI-----ACGVNLNSSRQSRIVGGESALPGAWPWQVSLH 311

  Fly   147 YTKSQGKKGHHCGGSLISTRYVITASHCVNGKALPTDW---------RLSGVRLGEWDTNTNPDC 202
            .     :..|.||||:|:..:::||:|||. |.|...|         |.|.:..|
Human   312 V-----QNVHVCGGSIITPEWIVTAAHCVE-KPLNNPWHWTAFAGILRQSFMFYG---------- 360

  Fly   203 EVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQVNDIALLRLAQQVEYTDFVRPICLPLDVNL 267
                          ....||:.|.||:|...:||  |||||::|.:.:.:.|.|:|:|||
Human   361 --------------AGYQVEKVISHPNYDSKTKN--NDIALMKLQKPLTFNDLVKPVCLP----- 404

  Fly   268 RSATFDGITMD------VAGWGKTEQLSASNLKLKAA-VEGFRMDECQNVYSSQDILLEDTQMCA 325
                ..|:.:.      ::|||.||:...::..|.|| |.......|.:.| ..|.|:....:||
Human   405 ----NPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRY-VYDNLITPAMICA 464

  Fly   326 GGKEG-VDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGPTPCGLAGWPGVYTLVGKYVDWI 386
            |..:| ||||:|||||||:   |:| |..::|.|..|:| :.|..|..||||..|..:.|||
Human   465 GFLQGNVDSCQGDSGGPLV---TSK-NNIWWLIGDTSWG-SGCAKAYRPGVYGNVMVFTDWI 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:463440	21/97 (22%)
		Tryp_SPc	128..389	CDD:238113	88/276 (32%)
TMPRSS2	NP_001128571.1	LDLa	150..185	CDD:238060	9/41 (22%)
		SRCR_2	190..283	CDD:464747	17/103 (17%)
		Tryp_SPc	293..524	CDD:238113	88/276 (32%)