DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and PRSS8

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_002764.1	Gene:	PRSS8 / 5652	HGNCID:	9491	Length:	343	Species:	Homo sapiens

Alignment Length:	284	Identity:	92/284 - (32%)
Similarity:	140/284 - (49%)	Gaps:	48/284 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 CGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHCVNGKALPTDW 184
            ||.....||.||......::||...|.|   :|.  |.|||||:|.::|::|:||     .|::.
Human    37 CGVAPQARITGGSSAVAGQWPWQVSITY---EGV--HVCGGSLVSEQWVLSAAHC-----FPSEH 91

  Fly   185 RLSG--VRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQVNDIALLRLA 247
            ....  |:||....::..: :..|..:||            .||||.|:  .:....|||||:|:
Human    92 HKEAYEVKLGAHQLDSYSE-DAKVSTLKD------------IIPHPSYL--QEGSQGDIALLQLS 141

  Fly   248 QQVEYTDFVRPICLPLDVNLRSATF-DGITMDVAGWGKTEQLSASNLKLK----AAVEGFRMDEC 307
            :.:.::.::||||||    ..:|:| :|:...|.|||.... |.|.|..|    ..|.....:.|
Human   142 RPITFSRYIRPICLP----AANASFPNGLHCTVTGWGHVAP-SVSLLTPKPLQQLEVPLISRETC 201

  Fly   308 QNVYS-----SQDILLEDTQMCAGGKE-GVDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGPTP 366
            ..:|:     .:...:::..:|||..| |.|:|:|||||||    :..|...::|.|:||:|..
Human   202 NCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPL----SCPVEGLWYLTGIVSWGDA- 261

  Fly   367 CGLAGWPGVYTLVGKYVDWIQNTI 390
            ||....||||||...|..|||:.:
Human   262 CGARNRPGVYTLASSYASWIQSKV 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	87/271 (32%)
		Tryp_SPc	128..389	CDD:238113	89/273 (33%)
PRSS8	NP_002764.1	Tryp_SPc	44..281	CDD:214473	87/271 (32%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	89/273 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910