DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ea and zgc:112038

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001018482.1	Gene:	zgc:112038 / 553673	ZFINID:	ZDB-GENE-050522-271	Length:	311	Species:	Danio rerio

Alignment Length:	288	Identity:	89/288 - (30%)
Similarity:	137/288 - (47%)	Gaps:	60/288 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 CGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHC------VNGK 178
            ||....|...||.......:||.|.|.....:   .|.||||||:..:|::|:||      .|.|
Zfish    27 CGQAPLNNNNGGDDAVAGSWPWQASIHRISPE---DHICGGSLINKDWVLSAAHCFMITATANIK 88

  Fly   179 ALPTDWRLSGVRLG-EWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIP----HPDYIPASKNQV 238
                      :.|| ::.|.:||:                  .:.||:.    ||||...::|
Zfish    89 ----------IFLGRQFQTGSNPN------------------EISRTLTQIVIHPDYSTTTQN-- 123

  Fly   239 NDIALLRLAQQVEYTDFVRPICLPLDVNLRSATFDGITMD-VAGWGK--TEQLSASNLKLKAAVE 300
            ||||||||:..|.:||::||:||.    ...:.|.|.|.. :.||.|  :..:..:|:..:..:.
Zfish   124 NDIALLRLSSSVTFTDYIRPVCLA----SADSVFAGGTKSWITGWDKHRSSDIQVTNVLQEVQLP 184

  Fly   301 GFRMDECQNVYSSQDILLEDTQMCAGGKE-GVDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGP 364
            .....||...|..   ::.|..:|||..| |.|:|:||||||::..:.::    :..:|:||||
Zfish   185 VVSNTECNADYKG---IITDNMICAGINEGGKDACQGDSGGPMVSQNGSR----WIQSGIVSFG- 241

  Fly   365 TPCGLAGWPGVYTLVGKYVDWIQNTIES 392
            ..|||..:||:||.|.:|..||.:.:.:
Zfish   242 RECGLPRYPGIYTRVSQYQSWITSELRT 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	84/273 (31%)
		Tryp_SPc	128..389	CDD:238113	86/275 (31%)
zgc:112038	NP_001018482.1	Tryp_SPc	37..263	CDD:214473	84/270 (31%)
zgc:112038	NP_001018482.1	Tryp_SPc	37..263	CDD:238113	84/270 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840