DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and f10

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001015728.1	Gene:	f10 / 548445	XenbaseID:	XB-GENE-971433	Length:	464	Species:	Xenopus tropicalis

Alignment Length:	358	Identity:	95/358 - (26%)
Similarity:	157/358 - (43%)	Gaps:	89/358 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 CGYTNGKVL-----ICCP-DRY-----------RESS------------------SETTPPPKPN 107
            |..|||.:|     .|.| ::|           ||:.                  ::|...|:.|
Frog   148 CSCTNGYILGENGKSCLPTEKYSCGRRHMKRERRETKLHENDKKNHTDSQNEVKMNQTGTLPERN 212

  Fly   108 VTS-NSLLPLPGQCGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITA 171
            ||. |.|.|      |..:.||.||.:....|.||.||:...:.:|    .|||:::|..:::||
Frog   213 VTGINILNP------NDPNVRIVGGRECSQGECPWQALLVSDEDEG----FCGGTILSREFILTA 267

  Fly   172 SHCVNGKALPTDWRLSGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKN 236
            :||:|      ..:...|.:||.:|..:...|...:             ||:.|.||.::.::.:
Frog   268 AHCMN------QTKYFKVVVGELNTKISEGTESIHK-------------VEKIIMHPRFVKSTYD 313

  Fly   237 QVNDIALLRLAQQVEYTDFVRPICLPLDVNLRSATFDGITMD-----VAGWGKTEQ--LSASNLK 294
            .  |||:::|.:.:.:|:.:.|.|:| |....    |.:.|:     |:|:|:..:  ..||.|:
Frog   314 Y--DIAVIKLKEAINFTENIIPACIP-DPEFA----DQVLMNEPDAMVSGFGRIHERGRQASTLQ 371

  Fly   295 LKAAVEGFRMDECQNVYSSQDILLEDTQMCAG-GKEGVDSCRGDSGGPLIGLDTNKVNTYYFLAG 358
            : ..|...:...|:   .|....:.:...||| ..|..|:|:||||||.:    ......||:.|
Frog   372 M-LQVPYIKRHSCK---ESSTFAITENMFCAGFDTEVKDACQGDSGGPHV----TPFKGTYFVTG 428

  Fly   359 VVSFGPTPCGLAGWPGVYTLVGKYVDWIQNTIE 391
            :||:| ..|...|..||||.|.|...|::..::
Frog   429 IVSWG-EGCARKGKFGVYTKVSKLHRWLKGVLK 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855	5/15 (33%)
		Tryp_SPc	127..386	CDD:214473	75/266 (28%)
		Tryp_SPc	128..389	CDD:238113	75/268 (28%)
f10	NP_001015728.1	GLA	22..84	CDD:214503
		EGF_CA	85..121	CDD:238011
		FXa_inhibition	128..163	CDD:373209	5/14 (36%)
		Tryp_SPc	228..456	CDD:238113	75/266 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010