Protein Alignment ea and ACR

DIOPT Version :10

• Sequence 1: NP_524362.2
• Gene: ea / 41858
• FlyBaseID: FBgn0000533
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_001088.2
• Gene: ACR / 49
• HGNCID: 126
• Length: 421
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 95/301 - (31%)
• Similarity: 149/301 - (49%)
• Gaps: 42/301 - (13%)

  Fly   105 KPNVTSNSLLPLPGQCG-NILSN-----RIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLI 163
            |.|.|.:      |.|| ....|     ||.||...:...:|||..::.......:.|.|||||:
Human    20 KDNATCD------GPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLL 78

  Fly   164 STRYVITASHCVNGKALPTDWRL-SGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPH 227
            ::|:|:||:||..||....|||| .|.:            |:.....|....|..:..||:.|.|
Human    79 NSRWVLTAAHCFVGKNNVHDWRLVFGAK------------EITYGNNKPVKAPLQERYVEKIIIH 131

  Fly   228 PDYIPASKNQVNDIALLRLAQQVEYTDFVRPICLPLDVNLRSATFDGI-TMDVAGWGKTEQLS-- 289
            ..|..|::.  |||||:.:...:....|:.|.|||   :.::....|. :..|||||..|:.:
Human   132 EKYNSATEG--NDIALVEITPPISCGRFIGPGCLP---HFKAGLPRGSQSCWVAGWGYIEEKAPR 191

  Fly   290 ASNLKLKAAVEGFRMDECQNV--YSSQDILLEDTQMCAGGKEG-VDSCRGDSGGPLIGLDTNKVN 351
            .|::.::|.|:...:|.|.:.  |:.:   ::.|.:|||...| :|:|:|||||||:..|:.:
Human   192 PSSILMEARVDLIDLDLCNSTQWYNGR---VQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKE-- 251

  Fly   352 TYYFLAGVVSFGPTPCGLAGWPGVYTLVGKYVDWIQNTIES 392
            :.|.:.|:.|:| ..|..|..||:||....|::||.:.|.|
Human   252 SAYVVVGITSWG-VGCARAKRPGIYTATWPYLNWIASKIGS 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:463440
		Tryp_SPc	128..389	CDD:238113	85/267 (32%)
ACR	NP_001088.2	Tryp_SPc	42..285	CDD:214473	84/265 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..316
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..383
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..421