DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and PRSS48

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_011530223.1	Gene:	PRSS48 / 345062	HGNCID:	24635	Length:	351	Species:	Homo sapiens

Alignment Length:	302	Identity:	92/302 - (30%)
Similarity:	139/302 - (46%)	Gaps:	69/302 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 SLLPLPGQCGN-ILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHH--CGGSLISTRYVITASH 173
            ||..|...||. :.|:|:.||.......:||...:.:       .|:  |||||:|.|.::||:|
Human    34 SLSSLSLVCGQPVYSSRVVGGQDAAAGRWPWQVSLHF-------DHNFICGGSLVSERLILTAAH 91

  Fly   174 CVNGKALPTDWR-------LSGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYI 231
            |:.    || |.       |..:.:|:                   :...:...|.:.:.||.|
Human    92 CIQ----PT-WTTFSYTVWLGSITVGD-------------------SRKRVKYYVSKIVIHPKY- 131

  Fly   232 PASKNQVNDIALLRLAQQVEYTDFVRPICLP-LDVNLRSATFDGITMDVAGWGKTEQLS----AS 291
               ::...|:|||:|:.||.:|..:.||||| :...|....|..:|    ||||.::.|    .|
Human   132 ---QDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVT----GWGKVKESSDRDYHS 189

  Fly   292 NLKLKAAVEGFRMDECQNVYSSQDILL-------EDTQMCAGGKEGV-DSCRGDSGGPLIGLDTN 348
            .|: :|.|.......|:.:|:...|.|       ::.::|||..:.: |||:|||||||    :.
Human   190 ALQ-EAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPL----SC 249

  Fly   349 KVNTYYFLAGVVSFGPTPCGLAGWPGVYTLVGKYVDWIQNTI 390
            .::..:...||||:| ..|| ...|||||.|..|..||..||
Human   250 HIDGVWIQTGVVSWG-LECG-KSLPGVYTNVIYYQKWINATI 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	82/280 (29%)
		Tryp_SPc	128..389	CDD:238113	83/282 (29%)
PRSS48	XP_011530223.1	Tryp_SPc	50..285	CDD:214473	82/280 (29%)
PRSS48	XP_011530223.1	Tryp_SPc	51..288	CDD:238113	83/282 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910