DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and F10

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_058839.1	Gene:	F10 / 29243	RGDID:	61850	Length:	482	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	102/408 - (25%)
Similarity:	160/408 - (39%)	Gaps:	107/408 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SIIC-----LFLGILAKSSAGQFYFPNEAAQVPNYGRCITPNRERALCIHLEDCKYLYGLLTTTP 64
            |::|     .|||...||......||           |...|:.||        |....|.|:..
  Rat   146 SVVCSCAKGYFLGNDGKSCLSTAPFP-----------CGKTNKGRA--------KRSVALNTSNS 191

  Fly    65 -------LRDTDRLYLSRSQCGYTNGKVLICCPDRYRESSSE--TTPPPKPNVTSNSLLPLPGQC 120
                   :.|.|.||.:                    ||.||  .....:|...|:.::
  Rat   192 EPDPEDLMPDADILYPT--------------------ESPSELLNLNKTEPEANSDDVI------ 230

  Fly   121 GNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHCVNGKALPTDWR 185
                  ||.||.:.|..|.||.||:   .|..:....|||::::..|::||:||::      ..:
  Rat   231 ------RIVGGQECKRGECPWQALL---FSDEETDGFCGGTILNEFYILTAAHCLH------QAK 280

  Fly   186 LSGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQVN----DIALLRL 246
            ...||:|:.:|......|:          .|   .|:..|.|      :|.|.:    |||:|||
  Rat   281 RFKVRVGDLNTEQEDGGEM----------VH---EVDMIIKH------NKFQRDTYDFDIAMLRL 326

  Fly   247 AQQVEYTDFVRPICLPLDVNLRSATFDGITMDVAGWGKTEQLSASNLKLK-AAVEGFRMDECQNV 310
            ...:.:.:.|.|.|||......:......|..|:|:|:|.:....:..|| ..|.....:.|:
  Rat   327 KTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCR-- 389

  Fly   311 YSSQDILLEDTQMCAG-GKEGVDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGPTPCGLAGWPG 374
             .|....:.....||| ..:..|:|:||||||.:    .:....||:.|:||:| ..|...|..|
  Rat   390 -LSTSFSITQNMFCAGYDAKQEDACQGDSGGPHV----TRFKDTYFVTGIVSWG-EGCARKGKYG 448

  Fly   375 VYTLVGKYVDWIQNTIES 392
            :||.|..::.||..::::
  Rat   449 IYTKVTAFLKWIDRSMKA 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855	11/58 (19%)
		Tryp_SPc	127..386	CDD:214473	74/264 (28%)
		Tryp_SPc	128..389	CDD:238113	75/266 (28%)
F10	NP_058839.1	GLA	23..84	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:405372	6/17 (35%)
		Tryp_SPc	232..462	CDD:238113	75/265 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920