DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and f10

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_958870.3	Gene:	f10 / 282670	ZFINID:	ZDB-GENE-021206-9	Length:	504	Species:	Danio rerio

Alignment Length:	291	Identity:	87/291 - (29%)
Similarity:	144/291 - (49%)	Gaps:	50/291 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VTSNSLLPLPGQCGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITAS 172
            :....:||:....|:   .||..|::....:.||.||:....:.|    .|||::::..::::|:
Zfish   228 IEEEPILPVVSTAGD---GRIVNGVECPPGDCPWQALLINENNMG----FCGGTILTEHFILSAA 285

  Fly   173 HCVNGKALPTDWRLS-GVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKN 236
            ||:|..       || .|.:||:||......|.          .|   .|:..:.|.:|.|.:.:
Zfish   286 HCMNES-------LSIRVVVGEYDTLVPEGREA----------TH---DVDEILIHKNYQPDTYH 330

  Fly   237 QVNDIALLRLAQQVEYTDFVRPICLPLDVNLRSATF----DGITMDVAGWGKTEQ--LSASNLKL 295
              |||||::|::.:::|.::.|.||| ::.......    ||:   |:|:|:..:  ||::.|:
Zfish   331 --NDIALIKLSKPIKFTKYIIPACLP-EMKFAERVLMQQDDGL---VSGFGRVREGGLSSTILQ- 388

  Fly   296 KAAVEGFRMDECQNVYSSQDILLEDTQMCAG-GKEGVDSCRGDSGGPLIGLDTNKVNTYYFLAGV 359
            |..|......:|   ..|.:..:.....||| .:|..|:|:||||||.:   |...|| :|:.||
Zfish   389 KLTVPYVNRAKC---IESSNFKISGRMFCAGYDQEEKDACQGDSGGPHV---TRFKNT-WFITGV 446

  Fly   360 VSFGPTPCGLAGWPGVYTLVGKYVDWIQNTI 390
            ||:| ..|...|..||||.|.||:.||.|.:
Zfish   447 VSWG-EGCARKGKYGVYTQVSKYIMWINNAM 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	81/266 (30%)
		Tryp_SPc	128..389	CDD:238113	82/268 (31%)
f10	NP_958870.3	GLA	19..82	CDD:214503
		EGF_CA	83..119	CDD:238011
		FXa_inhibition	126..161	CDD:291342
		Tryp_SPc	244..472	CDD:214473	81/266 (30%)
		Tryp_SPc	245..474	CDD:238113	82/267 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920