DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and PRSS33

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001372391.1	Gene:	PRSS33 / 260429	HGNCID:	30405	Length:	280	Species:	Homo sapiens

Alignment Length:	292	Identity:	97/292 - (33%)
Similarity:	139/292 - (47%)	Gaps:	68/292 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 CGN-ILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHCVNGKALPTD 183
            ||. .:|:||.||...:..|:||.|.|::     :..|.||||||:.::|:||:||...:|||.:
Human    28 CGQPRMSSRIVGGRDGRDGEWPWQASIQH-----RGAHVCGGSLIAPQWVLTAAHCFPRRALPAE 87

  Fly   184 W--RLSGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQVNDIALLRL 246
            :  ||..:|||                  ..:|..|.|||.|.:..|||  :......|:|||:|
Human    88 YRVRLGALRLG------------------STSPRTLSVPVRRVLLPPDY--SEDGARGDLALLQL 132

  Fly   247 AQQVEYTDFVRPICLPLDVNLRSATFDGITMDVAGWGKTEQLSASNLKLKAAV--------EGFR 303
            .:.|..:..|:|:|||:.   .:....|....|.|||          .|:..|        :|.|
Human   133 RRPVPLSARVQPVCLPVP---GARPPPGTPCRVTGWG----------SLRPGVPLPEWRPLQGVR 184

  Fly   304 MD-----ECQNVY-------SSQDILLEDTQMCAGGKEG-VDSCRGDSGGPLIGLDTNKVNTYYF 355
            :.     .|..:|       .::.|:|..: :|||..:| .|:|:|||||||..|.:..    :.
Human   185 VPLLDSRTCDGLYHVGADVPQAERIVLPGS-LCAGYPQGHKDACQGDSGGPLTCLQSGS----WV 244

  Fly   356 LAGVVSFGPTPCGLAGWPGVYTLVGKYVDWIQ 387
            |.||||:| ..|.|...|||||.|..|..|||
Human   245 LVGVVSWG-KGCALPNRPGVYTSVATYSPWIQ 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	91/281 (32%)
		Tryp_SPc	128..389	CDD:238113	93/283 (33%)
PRSS33	NP_001372391.1	Tryp_SPc	37..275	CDD:238113	91/281 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910