DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and TPSD1

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_036349.1	Gene:	TPSD1 / 23430	HGNCID:	14118	Length:	242	Species:	Homo sapiens

Alignment Length:	269	Identity:	78/269 - (28%)
Similarity:	105/269 - (39%)	Gaps:	87/269 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 PLPGQCGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKG----HHCGGSLISTRYVITASHCV 175
            |.|||.  :....|.||.:....::||...:..      :|    |.||||||..::|:||:|||
Human    27 PAPGQA--LQQTGIVGGQEAPRSKWPWQVSLRV------RGPYWMHFCGGSLIHPQWVLTAAHCV 83

  Fly   176 NGKALPTDWRLSGVRLGEWDTNTNPDCEVDVRGMKDCA-------PPHLD-----VPVERTIPHP 228
                                   .||       :||.|       ..||.     :||.|.|.||
Human    84 -----------------------EPD-------IKDLAALRVQLREQHLYYQDQLLPVSRIIVHP 118

  Fly   229 DYIPASKNQVNDIALLRLAQQVEYTDFVRPICLPLDVNLRSATF-DGITMDVAGWGKTEQLSASN 292
            .:.......  |||||.|.:.|..:..:..:.||    ..|.|| .|:...|.|||..:    :|
Human   119 QFYIIQTGA--DIALLELEEPVNISSHIHTVTLP----PASETFPPGMPCWVTGWGDVD----NN 173

  Fly   293 LKL-------KAAVEGFRMDECQNVY--------SSQDILLEDTQMCAGGKEGVDSCRGDSGGPL 342
            :.|       :..|.......|...|        |.|  ::.|..:|| |.|..|||:|||||||
Human   174 VHLPPPYPLKEVEVPVVENHLCNAEYHTGLHTGHSFQ--IVRDDMLCA-GSENHDSCQGDSGGPL 235

  Fly   343 IGLDTNKVN 351
            :    .|||
Human   236 V----CKVN 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	74/257 (29%)
		Tryp_SPc	128..389	CDD:238113	74/256 (29%)
TPSD1	NP_036349.1	Tryp_SPc	38..242	CDD:238113	74/256 (29%)
TPSD1	NP_036349.1	Tryp_SPc	38..240	CDD:214473	72/254 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840