DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and F10

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	418	Identity:	113/418 - (27%)
Similarity:	173/418 - (41%)	Gaps:	92/418 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EAAQVPNYGRCITPNRERALCIHLE-----DCKYLYGLLTTTPLRDTDRLYLSRSQ------C-- 78
            |.:...|.|:|.....|.. |..||     :|:.....|.:....|.|: :....|      |
Human    91 ETSPCQNQGKCKDGLGEYT-CTCLEGFEGKNCELFTRKLCSLDNGDCDQ-FCHEEQNSVVCSCAR 153

  Fly    79 GYT---NGKVLICCP-----------DRYRESSSETTPPP---------KP------NVTSN--S 112
            |||   |||.  |.|           :|.:.|.::.|...         ||      :.|.|  .
Human   154 GYTLADNGKA--CIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFD 216

  Fly   113 LLPL----PGQCGNILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASH 173
            ||..    |.:..|.|: ||.||.:.|..|.||.||:...:::|    .|||:::|..|::||:|
Human   217 LLDFNQTQPERGDNNLT-RIVGGQECKDGECPWQALLINEENEG----FCGGTILSEFYILTAAH 276

  Fly   174 CV-NGKALPTDWRLSGVRLGEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQ 237
            |: ..|...       ||:|:.:|......|.          .|   .||..|.|..:   :|..
Human   277 CLYQAKRFK-------VRVGDRNTEQEEGGEA----------VH---EVEVVIKHNRF---TKET 318

  Fly   238 VN-DIALLRLAQQVEYTDFVRPICLPLDVNLRSATFDGITMDVAGWGKTEQLSASNLKLK-AAVE 300
            .: |||:|||...:.:...|.|.|||......|......|..|:|:|:|.:....:.:|| ..|.
Human   319 YDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVP 383

  Fly   301 GFRMDECQNVYSSQDILLEDTQMCAG-GKEGVDSCRGDSGGPLIGLDTNKVNTYYFLAGVVSFGP 364
            ....:.|:   .|...::.....||| ..:..|:|:||||||.:    .:....||:.|:||:|
Human   384 YVDRNSCK---LSSSFIITQNMFCAGYDTKQEDACQGDSGGPHV----TRFKDTYFVTGIVSWG- 440

  Fly   365 TPCGLAGWPGVYTLVGKYVDWIQNTIES 392
            ..|...|..|:||.|..::.||..::::
Human   441 EGCARKGKYGIYTKVTAFLKWIDRSMKT 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855	17/67 (25%)
		Tryp_SPc	127..386	CDD:214473	77/262 (29%)
		Tryp_SPc	128..389	CDD:238113	78/264 (30%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011	8/31 (26%)
		FXa_inhibition	129..164	CDD:317114	10/37 (27%)
		O-glycosylated at one site	183..203		3/19 (16%)
		Tryp_SPc	235..464	CDD:238113	78/263 (30%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920