DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ea and PRSS21

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_006790.1	Gene:	PRSS21 / 10942	HGNCID:	9485	Length:	314	Species:	Homo sapiens

Alignment Length:	304	Identity:	91/304 - (29%)
Similarity:	136/304 - (44%)	Gaps:	62/304 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 KPNVTSNSLLPLPGQCG-NILSNRIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYV 168
            ||.  |....||.|.|| .::::||.||...::..:||...:....|     |.||.||:|.|:.
Human    20 KPE--SQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDS-----HVCGVSLLSHRWA 77

  Fly   169 ITASHC---VNGKALPTDWRLSGVRLGE-------WDTNTNPDCEVDVRGMKDCAPPHLDVPVER 223
            :||:||   .:..:.|:.|.   |:.|:       |.....                :....|..
Human    78 LTAAHCFETYSDLSDPSGWM---VQFGQLTSMPSFWSLQAY----------------YTRYFVSN 123

  Fly   224 TIPHPDYIPASKNQVNDIALLRLAQQVEYTDFVRPICLPLDVNLRSATFDGITMD---VAGWG-- 283
            ....|.|:   .|...||||::|:..|.||..::|||      |:::||:.....   |.|||
Human   124 IYLSPRYL---GNSPYDIALVKLSAPVTYTKHIQPIC------LQASTFEFENRTDCWVTGWGYI 179

  Fly   284 -KTEQLSASNLKLKAAVEGFRMDECQNV---YSSQDILLEDTQMCAGGKE-GVDSCRGDSGGPLI 343
             :.|.|.:.:...:..|.......|.::   ||.:..:..| .:|||..: |.|:|.|||||||.
Human   180 KEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD-MVCAGNAQGGKDACFGDSGGPLA 243

  Fly   344 GLDTNKVNTYYFLAGVVSFGPTPCGLAGWPGVYTLVGKYVDWIQ 387
               .|| |..::..||||:| ..||....|||||.:..:.:|||
Human   244 ---CNK-NGLWYQIGVVSWG-VGCGRPNRPGVYTNISHHFEWIQ 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	80/278 (29%)
		Tryp_SPc	128..389	CDD:238113	82/280 (29%)
PRSS21	NP_006790.1	Tryp_SPc	42..283	CDD:238113	82/280 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910