DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ea and proc.2

DIOPT Version :9

Sequence 1:	NP_524362.2	Gene:	ea / 41858	FlyBaseID:	FBgn0000533	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001120289.1	Gene:	proc.2 / 100145345	XenbaseID:	XB-GENE-5882297	Length:	681	Species:	Xenopus tropicalis

Alignment Length:	268	Identity:	96/268 - (35%)
Similarity:	136/268 - (50%)	Gaps:	39/268 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 RIYGGMKTKIDEFPWMALIEYTKSQGKKGHHCGGSLISTRYVITASHCVNGKALPTDWRLSGVRL 191
            ||.|||:.::.:.||..||...:..|    .|||||||:|:|::|:||...: :|     ..|.:
Frog   435 RIVGGMRCELGQCPWQVLIRNNRGFG----FCGGSLISSRWVLSAAHCFESQ-IP-----HHVTI 489

  Fly   192 GEWDTNTNPDCEVDVRGMKDCAPPHLDVPVERTIPHPDYIPASKNQVNDIALLRLAQQVEYTDFV 256
            |::||...     |:...|        :.|.:...||:|:  ::...:|||||.|.....:.::.
Frog   490 GDYDTYRR-----DMDEQK--------IAVLQVFSHPNYL--AEFYDHDIALLFLRSPAMFGEYS 539

  Fly   257 RPICLPLDVNLRSATFDGITMDVAGWGKTEQLSA-SNLKLKAAVEGFRMDECQNVYSSQDILLED 320
            ||||||.....:..|.:|.|..|:|||.|.|... :...||..:.....:.|.   :|.:.:|..
Frog   540 RPICLPNPGLGKMLTQEGQTGQVSGWGATRQFGPYTRFLLKVRLPIVSQETCM---ASTENILTG 601

  Fly   321 TQMCAGGKEGV-DSCRGDSGGPLIGL--DTNKVNTYYFLAGVVSFGPTPCGLAGWPGVYTLVGKY 382
            ...|||.|||| |:|.||||||...|  ||      :||.||||:| ..|...|..||||.|..|
Frog   602 NMFCAGYKEGVKDACSGDSGGPFAVLFHDT------WFLVGVVSWG-DGCAEKGKYGVYTRVANY 659

  Fly   383 VDWIQNTI 390
            :.||:.||
Frog   660 MPWIKETI 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ea	NP_524362.2	CLIP	37..89	CDD:288855
		Tryp_SPc	127..386	CDD:214473	92/262 (35%)
		Tryp_SPc	128..389	CDD:238113	93/264 (35%)
proc.2	NP_001120289.1	GLA	19..80	CDD:214503
		EGF_CA	81..117	CDD:238011
		FXa_inhibition	123..160	CDD:373209
		Tryp_SPc	436..666	CDD:238113	93/264 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920