DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6236 and T07G12.3

DIOPT Version :9

Sequence 1:	NP_650446.2	Gene:	CG6236 / 41857	FlyBaseID:	FBgn0038318	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_501945.2	Gene:	T07G12.3 / 188242	WormBaseID:	WBGene00011594	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	703	Identity:	156/703 - (22%)
Similarity:	275/703 - (39%)	Gaps:	142/703 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VVVLLVTWYVLNVERDLDKSLKIE---IIERSIRSAVNRGECRHP---HLPLDNPDIMKFYKPVE 76
            :::..:.:|:|:.....:.|.|||   :...|.|||.|  .|..|   :......::|..|.|..
Worm    10 ILLAFLGFYMLSWRSFNNGSTKIESKFLYLDSSRSAHN--ICALPIYDYWDTSIKNVMHEYNPAR 72

  Fly    77 RINCGEG-MDWVMCEKSICFVRPEIASSHEDVICSYTDIIRKSDYKVRFGQSLR----MKEPYVL 136
              ||.:. :.|.           |:.:|...::....:.:.:....:...::::    ||..:|
Worm    73 --NCYKNYVQWT-----------ELVNSTWRIVKDGANCLARCFSGIGGSKNVKIGPWMKPGHV- 123

  Fly   137 QASDFVKVVCRSSSGESWFGMAHGIRDTVPRPPASNFSPNLAVLPPEAVAQAQQQMQDGATAPIY 201
             ..:|::.||...:.|. :|..|  ...:||    ..||.              :.:|   ||
Worm   124 -DCEFLETVCWEDNIEV-YGHIH--TQIIPR----KASPT--------------KFKD---AP-- 161

  Fly   202 NVLMFGFDSLSRNAFIRKLPRTYEYLTQQLGATVLKGYNIVGDGTPQALVPLLTGFTELELPETR 266
            ||.:|..|:::.....|..|:...|...:.........|.||:.:....:||..|    :..|..
Worm   162 NVFIFTIDAMNTGMAKRSFPKLLSYFKNEFQMIEFPFVNKVGENSRPNGLPLWFG----KSIEGG 222

  Fly   267 KRLSG-------------AGSVDSYPMIWKDFARLGYMTSFNEDLP-NVGTFTYRMTGFEAQPVD 317
            :|::|             ...:|:...|:|||...||.|...||.. ||........|||..|.|
Worm   223 RRVTGDDVEVDWDWNQYCETYLDNSSHIFKDFKDHGYATMLFEDWEGNVVDSWPTCVGFEEPPTD 287

  Fly   318 HYLRTY-YVQAEHMAAESKPNCIGH--QPDHITMLEYTKNFMLKYRDAPRFAFSFHGGLSHDSIN 379
            |..|.: .|...|....:|.:..|.  :..|..::|..:..:..|:|.|.|::.:...::||.|:
Worm   288 HTFRPFASVSETHGMEITKRHLSGKFCRETHHAIMELLEQGIEAYKDRPIFSWLWLAWVAHDWID 352

  Fly   380 LVGAADDDVHDWLVAL--KERSLLDDTILIMMADHGNRFAEVRATLQGKQEERLPFFSFVFPESF 442
              |||  .|.::||..  |..::.|::.::.::|||.|..:...|..|..|...||.|...|:.|
Worm   353 --GAA--RVDEYLVNYFKKHNNMFDNSFVMFVSDHGLRTGKHMRTEIGAFERDNPFLSISIPKRF 413

  Fly   443 K--KRFPQEYKNFLANEHHLTTPFDIHATLKHVIQLQTAVDQFGEINDPKTETSPPGIRISELAR 505
            :  |....|..||  :...|.|.||:.|||..:::.|..    .:..|.:.:..|.       .:
Worm   414 RATKFGILETLNF--DSKQLQTHFDVRATLLDILKFQPT----SKFMDRQQKNIPD-------EK 465

  Fly   506 GRAMSLLDP-IPSNRSCADAYIEPHWCACLNWLPLQLNDSRYTGIILK--AAQSIVNAIN--LAT 565
            |.::....| .|  |:||...|...||.|      |::........||  ..:.::|.::  |..
Worm   466 GHSLIRKQPDFP--RTCATLPIPQQWCIC------QVDKFEIHNETLKNHLGEKLLNHVHRKLKK 522

  Fly   566 VEQRQYCAPLEIHRVNWALRLQPHKELLQFRTNSDRDGFLADMTGQTLVRDEMYQLQV-VTMPGE 629
            :...:.|....:.:|.         .|:::       |::..|        ..|::.| .|:...
Worm   523 LNVSEICETFRLSKVT---------SLIEY-------GYVRTM--------RTYKISVETTISSY 563

  Fly   630 GLFEASVAYSLHTFSATTKLTDISRVNKYGNQARCIYDRDPELRK--YCYCRD 680
            ..||..|.|.:.|..|  |...::|::.|.....|    ...:|:  .|||::
Worm   564 AHFETFVTYDIETDIA--KFEKVTRLDNYAMTTDC----TKPIRQSPLCYCKN 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6236	NP_650446.2	DUF229	73..581	CDD:281053	120/538 (22%)
CG6236	NP_650446.2	ALP_like	201..477	CDD:293745	79/296 (27%)
T07G12.3	NP_501945.2	DUF229	67..538	CDD:281053	121/540 (22%)
T07G12.3	NP_501945.2	ALP_like	161..448	CDD:293745	80/298 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910