DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6236 and F07C3.3

DIOPT Version :9

Sequence 1:	NP_650446.2	Gene:	CG6236 / 41857	FlyBaseID:	FBgn0038318	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_505391.4	Gene:	F07C3.3 / 184124	WormBaseID:	WBGene00017194	Length:	746	Species:	Caenorhabditis elegans

Alignment Length:	693	Identity:	170/693 - (24%)
Similarity:	285/693 - (41%)	Gaps:	147/693 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ERDLDKSLKIEII--ERSIRSAVNRGE--CRHP-----HLPLDN---PDIMKFYKPVERINCGEG 83
            |..:||...|.:.  :.:|::.:.|..  ..||     ..||.|   .||:.|:       ..|.
Worm    60 ESAIDKLWNINVFGDDDNIKTEIERDPLLTHHPFDNTCKFPLPNSYAEDIIPFH-------LSER 117

  Fly    84 MDWVMCE-----------KSICFVRPEIAS---SHEDVICSYTDIIRKSDYKVRFGQSLRMKEPY 134
            |..:.||           :...:|.|....   ...||.|. .|||.         ..||..|..
Worm   118 MRQLKCEVKQKDYATMDSEGYIYVHPHFVDWPRLERDVQCK-VDIIE---------GGLRKPERN 172

  Fly   135 VLQASDFVKVVCRSSSGESWFGMA------------HGIRDTVP---RPPASNFSPNLAVLPPEA 184
            :.:.|.|:|......|.|..|..|            ..::..||   :|.......|   ||.:.
Worm   173 MTKNSMFIKKTLEIPSNERLFVNADAFVINCYNHSKKAVKPEVPIWKKPFPGMKDKN---LPEDE 234

  Fly   185 VAQAQQ-----------QMQDGATAPIYNVLMFGFDSLSRNAFIRKLPRTYEYLTQQLGATVLKG 238
            :.:.:.           :.|.......|::.:.||||.:|..|:|.:|||.|.:. :|....|.|
Worm   235 ILRVKDLYSYGDYGNKIREQVSKAVDRYSIDILGFDSTARTMFMRHMPRTVEVMA-KLDYHYLYG 298

  Fly   239 YNIVGDGTPQALVPLLTGFTELELPETRKRLSGAGSVD------------SYPMIWKDF-ARLGY 290
            |..|.|.:...|.|:|.|..|..|.:.:...||..:::            ....:||.. .:.|.
Worm   299 YTKVADNSMVNLAPILVGDMEEALKKPKYDKSGDFNINWLLPTEDKMDPTKLNFLWKIMKEKYGC 363

  Fly   291 MTSFNEDL--PNVGTFTYRMT----GFEAQPVDHYLRTYYVQA-EHMAAESKPNCIGHQPDHITM 348
            .:.||||:  ..:|.|.|..|    ||...|.|||.|.||:.. |:...|:   |...:......
Worm   364 ESLFNEDISTKGLGLFNYPPTEFQPGFTENPADHYYRAYYLAVYENWKYEA---CRDGEQLQNEF 425

  Fly   349 LEYTKNFMLKYRDAPRFAFSFHGGLSHDSINLVGAADDDVHDWLVALKERSLLDDTILIMMADHG 413
            :...:.|..:||:...|.|:|...|:|::..::...|:.:...|..:.....||:|:.|:|.|||
Worm   426 VNIWRRFAHRYRNICHFGFTFVTTLTHEAGLVLEILDEKLAAHLSQMHLNGDLDNTLSIIMGDHG 490

  Fly   414 NRFAEVRATLQGKQEERLPFFSFVFPESFKKRFPQEYKNFLANEHHLTTPFDIHATLKHVIQLQT 478
            ||...:::...|:.|||:|..:..||..|.:.:|.||||||.|:|.||:.||:|.||..::.::
Worm   491 NRIGAIKSRYTGRIEERMPLMAMRFPTGFAETYPVEYKNFLDNKHKLTSNFDVHKTLHDIVHMR- 554

  Fly   479 AVDQFGEINDPKTETSPPGIRISELARGRAMSLLDPIPSNRSCADAYIEPHWCACL-------NW 536
                   :.|.|.::.          .||.:||.|.||:.|:|||..:..::|.|:       |.
Worm   555 -------LGDNKAKSD----------EGRGISLFDAIPNTRTCADVIVPENFCMCMIDVSSIANP 602

  Fly   537 LPLQLNDSRYTG------IILKA---AQSIVNAINLATVEQRQYCAPLEIHRVN-WALRLQPHKE 591
            || ..|..:.|.      ..||:   .:::.:.::::::|..|....:.|:.:: :.||.:.:..
Worm   603 LP-NFNKKKPTDQKMDQFNTLKSWLKTENLDDCVDVSSLETGQTFQEMAINPLSRFGLRTKNNAS 666

  Fly   592 LLQFRTNSDRD-------GFLADMTG--------QTLVRDEMY 619
            :|:.....::.       .|...::|        ..|||.|::
Worm   667 MLELMKERNKKNPELNYINFEFSVSGTYKNGEPLSMLVRTELF 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6236	NP_650446.2	DUF229	73..581	CDD:281053	147/583 (25%)
CG6236	NP_650446.2	ALP_like	201..477	CDD:293745	93/295 (32%)
F07C3.3	NP_505391.4	DUF229	75..623	CDD:308570	152/590 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910