DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6236 and F10C2.3

DIOPT Version :9

Sequence 1:	NP_650446.2	Gene:	CG6236 / 41857	FlyBaseID:	FBgn0038318	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_506015.2	Gene:	F10C2.3 / 179650	WormBaseID:	WBGene00008644	Length:	604	Species:	Caenorhabditis elegans

Alignment Length:	692	Identity:	173/692 - (25%)
Similarity:	293/692 - (42%)	Gaps:	175/692 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CVVVLLVTW------YVLN--------------VERD---LDKSLKIEIIERSIRSAVNRGECRH 58
            |||..|..|      |||:              |:.:   ||::..:::...::..:..:.||::
Worm    50 CVVPTLDPWDQSILEYVLDDGSRPTQLACHDAKVQPELTFLDENGVLQLNSTAVSESSLKVECQY 114

  Fly    59 -PHLPLDNPDIMKFYKPVERINCGEGMDWVMCEKSICFVRPEIASSHEDVICSYTDIIRKSDYKV 122
             .:..:|..|        |::|..|   |                                   :
Worm   115 RTYDKMDGDD--------EQLNYSE---W-----------------------------------I 133

  Fly   123 RFGQSLRMKEPYVLQASDFVKVVCRSSSGESWFGMAHGIRDTVPRPPASNFSPNLAVLPPEAVAQ 187
            .|..|::::       |:||:|.|:    .:||          ||....:.:.| .::|    ..
Worm   134 SFNMSVKIE-------SEFVEVSCQ----RAWF----------PRTKVYSNNHN-QIIP----IS 172

  Fly   188 AQQQMQDGATAPIYNVLMFGFDSLSRNAFIRKLPRTYEYLTQQLGATVLKGYNIVGDGTPQALVP 252
            ..|.:.|.:     :|::...||:|.:.|.|.:.:|.:.:....|:.:..|...:||.:....|.
Worm   173 RSQPVSDKS-----SVIVIVLDSVSHSNFRRTMNKTLDVMHSLYGSFIFDGMTKIGDNSFSNAVG 232

  Fly   253 LLTG-FTELELPETRKRLSGAGSVDSYPMIWKDFARLGYMTSFNEDLPNVGTFTYRMTGFEAQPV 316
            ...| :...|..:..      |..|.:.:|||.:...||.|.:.||.|....|.|...||:.:||
Worm   233 FFAGKWWNTEFGDAH------GYFDDHDLIWKHYRENGYRTLYAEDYPGFNLFNYLSKGFKKKPV 291

  Fly   317 DHYLRTYYVQA--EHMAAESKPNCIGHQPDHITMLEYTKNFMLKYRDAPRFAFSFHGGLSHDSIN 379
            |||.|.|::..  .::...|:..|.|:...|...|.|...|:.||:|.|:||.|:...|.||.:|
Worm   292 DHYFRPYWLNVYWTYVHRRSRNLCYGNHRMHNLQLNYLSQFVSKYKDQPKFAISWLTELGHDWLN 356

  Fly   380 LVGAADDDVHDWLVALKERSLLDDTILIMMADHGNRFAEVRATLQGKQEERLPFFSFVFPESFKK 444
            .|...|:|:.::|  .|....|:::.|.:|:|||:||..:|.|..|:.||||||||...|:..:|
Worm   357 QVRYGDEDLANFL--KKHVEDLENSYLFIMSDHGHRFDNIRKTSIGRLEERLPFFSVSLPKKLRK 419

  Fly   445 RFPQEYKNFLANEHHLTTPFDIHATLKHVIQLQTAVDQFGEINDPKTETSPPGIRISELARGRAM 509
            . .:.......|...||:.||::||.:|:            :|:.|.         .::.||.::
Worm   420 D-SKLVDTVRKNSKKLTSFFDVYATFRHI------------LNNSKQ---------PDVMRGESL 462

  Fly   510 SLLDPIPSNRSCADAYIEPHWCACLNWLPLQLNDSRYTGIILKAAQSIVNAINLATVEQRQYCAP 574
            .|  || .:|:|..|:|...:|.|...:||.::.:..   |...|:.....||
Worm   463 FL--PI-KDRNCETAHIPEEFCVCDTEVPLNVSANAQ---IRTMAEDFAKDIN------------ 509

  Fly   575 LEIHRVNWALRLQPHKELLQFRTNSDRDGFLADMTGQTL---VRDEMYQLQVVTMPGEGLFEASV 636
                     .||.||.:.:|.        :|.::...:.   |:::.|:..:...|...:|||.:
Worm   510 ---------QRLDPHPQCVQL--------YLKNVISVSQVGDVKEQRYRFTIEVSPSNAIFEALL 557

  Fly   637 AYSLHTFSATTKLTDISRVNKYGNQARCIYDRDPELRKYCYC 678
            .|.... |.||.:.||:|:||||||:.|:  :|..|||.|:|
Worm   558 LYDPFE-SQTTVIGDINRINKYGNQSLCV--QDQFLRKLCFC 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6236	NP_650446.2	DUF229	73..581	CDD:281053	126/510 (25%)
CG6236	NP_650446.2	ALP_like	201..477	CDD:293745	88/278 (32%)
F10C2.3	NP_506015.2	DUF229	110..527	CDD:281053	136/558 (24%)
F10C2.3	NP_506015.2	ALP_like	182..451	CDD:293745	89/289 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391133at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920