DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm2 and EDE1

DIOPT Version :9

Sequence 1:	NP_001262592.1	Gene:	Tm2 / 41853	FlyBaseID:	FBgn0004117	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_009506.1	Gene:	EDE1 / 852233	SGDID:	S000000143	Length:	1381	Species:	Saccharomyces cerevisiae

Alignment Length:	214	Identity:	47/214 - (21%)
Similarity:	96/214 - (44%)	Gaps:	23/214 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AKEQLEKANTELEEKEKLLTATESEVATQNRKVQQIEEDLEKSEERSTTAQQKLLEATQSADENN 124
            |..||..|.||:......:.:...:.:..|.|..:..::|::..|...:.|.||.....:.|:|.
Yeast   595 ASAQLSNATTEMANLSNQVNSLSKQASITNDKKSRATQELKRVTEMKNSIQIKLNNLRSTHDQNV 659

  Fly   125 RMCKVLENRSQQDEERMDQLTNQLKEARMLAEDADTKSDEVSRKLAFVEDELEVAEDRVRSGESK 189
            :..:.||.:..|..:..:.|..||..:......|::|.:|::..|              :..::|
Yeast   660 KQTEQLEAQVLQVNKENETLAQQLAVSEANYHAAESKLNELTTDL--------------QESQTK 710

  Fly   190 IMELEEELKVVGNSLKSLEVS-EEKANQRVEEFKREMKTLSIKLKEAEQRAEHAEKQVKRLQKEV 253
            ..||:|::    .:|.|:..| :.:.|::.::.|:|...:.:..|:.|..    :..|..||||:
Yeast   711 NAELKEQI----TNLNSMTASLQSQLNEKQQQVKQERSMVDVNSKQLELN----QVTVANLQKEI 767

  Fly   254 DRLEDELGINKDRYKSLAD 272
            |.|.:::.:...:.|.|.|
Yeast   768 DGLGEKISVYLTKQKELND 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm2	NP_001262592.1	Tropomyosin	48..281	CDD:395200	47/214 (22%)
EDE1	NP_009506.1	EH	9..101	CDD:197477
		EH	128..221	CDD:197477
		EH	270..363	CDD:197477
		Atrophin-1	<355..>528	CDD:397323
		Smc	<595..877	CDD:224117	47/214 (22%)
		PRK08581	903..>1111	CDD:236304
		UBA_scEDE1_like	1345..1379	CDD:270471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910