DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm2 and TPM1

DIOPT Version :9

Sequence 1:	NP_001262592.1	Gene:	Tm2 / 41853	FlyBaseID:	FBgn0004117	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001352707.1	Gene:	TPM1 / 7168	HGNCID:	12010	Length:	326	Species:	Homo sapiens

Alignment Length:	323	Identity:	136/323 - (42%)
Similarity:	194/323 - (60%)	Gaps:	42/323 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAIKKKMQAMKLEKDNAIDKADTCENQAKDANSRADKLNEEV-------------RD------- 45
            |||||||||.:||:|:||:|:|:..|...|.|..|:.:|.|::             ||
Human     1 MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELH 65

  Fly    46 ----------------------LEKKFVQVEIDLVTAKEQLEKANTELEEKEKLLTATESEVATQ 88
                                  |:||....|.:|....|.|:.|..:||..||..|..|::||:.
Human    66 KAEDSLLAAEEAAAKLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASL 130

  Fly    89 NRKVQQIEEDLEKSEERSTTAQQKLLEATQSADENNRMCKVLENRSQQDEERMDQLTNQLKEARM 153
            ||::|.:||:|::::||..||.|||.||.::|||:.|..||:|:|:|:|||:|:....|||||:.
Human   131 NRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKH 195

  Fly   154 LAEDADTKSDEVSRKLAFVEDELEVAEDRVRSGESKIMELEEELKVVGNSLKSLEVSEEKANQRV 218
            :|||||.|.:||:|||..:|.:||.||:|....|.|..|||||||.|.|:|||||...||.:|:.
Human   196 IAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKE 260

  Fly   219 EEFKREMKTLSIKLKEAEQRAEHAEKQVKRLQKEVDRLEDELGINKDRYKSLADEMDSTFAEL 281
            :.::.|:|.||.||||||.|||.||:.|.:|:|.:|.||:::...|:...|:...:|.|..||
Human   261 DRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLEL 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm2	NP_001262592.1	Tropomyosin	48..281	CDD:395200	109/232 (47%)
TPM1	NP_001352707.1	8a0101	1..>159	CDD:273385	54/157 (34%)
TPM1	NP_001352707.1	Tropomyosin	90..324	CDD:365985	111/234 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147725
Domainoid	1	1.000	247	1.000	Domainoid score	I2154
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48449
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8448
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.720