DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm2 and Tm1

DIOPT Version :9

Sequence 1:	NP_001262592.1	Gene:	Tm2 / 41853	FlyBaseID:	FBgn0004117	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster

Alignment Length:	294	Identity:	149/294 - (50%)
Similarity:	190/294 - (64%)	Gaps:	41/294 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DNAIDKADTCENQAKD-----ANSRADKL--NEEVR---------------------DLEKKFVQ 52
            |..|..||..:|||.:     ..|.|.::  ..|.|                     |...||..
  Fly   427 DEGIALADDDDNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNI 491

  Fly    53 VEIDLVTAKEQLEKANTELEEKEKLLTATESEVATQNRKVQQIEEDLEKSEERSTTAQQKLLEAT 117
            :..:|...      .||:|:.       .|||||..||::|.:|||||:||||..:|..||.||:
  Fly   492 IRNELHNI------MNTQLKR-------AESEVAALNRRIQLLEEDLERSEERLGSATAKLSEAS 543

  Fly   118 QSADENNRMCKVLENRSQQDEERMDQLTNQLKEARMLAEDADTKSDEVSRKLAFVEDELEVAEDR 182
            |:|||:.|..|:||||:..||||||.|.|||||||.|||:||.|.|||:||||.||.:||.||:|
  Fly   544 QAADESERARKILENRALADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEER 608

  Fly   183 VRSGESKIMELEEELKVVGNSLKSLEVSEEKANQRVEEFKREMKTLSIKLKEAEQRAEHAEKQVK 247
            ...||:||:||||||:||||:||||||||||||||.||:|.::|||:.:|||||.|||.||:.|:
  Fly   609 AEQGENKIVELEEELRVVGNNLKSLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQ 673

  Fly   248 RLQKEVDRLEDELGINKDRYKSLADEMDSTFAEL 281
            :||||||||||:|.:.|:|||.:.|::|:.|.||
  Fly   674 KLQKEVDRLEDDLVLEKERYKDIGDDLDTAFVEL 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm2	NP_001262592.1	Tropomyosin	48..281	CDD:395200	135/232 (58%)
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	89/130 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449910
Domainoid	1	1.000	245	1.000	Domainoid score	I2136
eggNOG	1	0.900	-	-		E1_KOG1003
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm6508
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	P	PTHR19269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X463
	10	9.750