DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm2 and Tpm1

DIOPT Version :9

Sequence 1:	NP_001262592.1	Gene:	Tm2 / 41853	FlyBaseID:	FBgn0004117	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_038936768.1	Gene:	Tpm1 / 24851	RGDID:	3898	Length:	294	Species:	Rattus norvegicus

Alignment Length:	281	Identity:	136/281 - (48%)
Similarity:	197/281 - (70%)	Gaps:	0/281 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAIKKKMQAMKLEKDNAIDKADTCENQAKDANSRADKLNEEVRDLEKKFVQVEIDLVTAKEQLE 65
            |||||||||.:||:|:||:|:|:..|...|.|..|:.:|.:|:..|:||....|.:|....|.|:
  Rat     1 MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALK 65

  Fly    66 KANTELEEKEKLLTATESEVATQNRKVQQIEEDLEKSEERSTTAQQKLLEATQSADENNRMCKVL 130
            .|..:||..||..|..|::||:.||::|.:||:|::::||..||.|||.||.::|||:.|..||:
  Rat    66 DAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVI 130

  Fly   131 ENRSQQDEERMDQLTNQLKEARMLAEDADTKSDEVSRKLAFVEDELEVAEDRVRSGESKIMELEE 195
            |:|:|:|||:|:....|||||:.:|||||.|.:||:|||..:|.:||.||:|....|.|..||||
  Rat   131 ESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEE 195

  Fly   196 ELKVVGNSLKSLEVSEEKANQRVEEFKREMKTLSIKLKEAEQRAEHAEKQVKRLQKEVDRLEDEL 260
            |||.|.|:|||||...||.:|:.::::.|:|.||.||||||.|||.||:.|.:|:|.:|.|||||
  Rat   196 ELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDEL 260

  Fly   261 GINKDRYKSLADEMDSTFAEL 281
            ...|.:||::::|:|....::
  Rat   261 YAQKLKYKAISEELDHALNDM 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm2	NP_001262592.1	Tropomyosin	48..281	CDD:395200	113/232 (49%)
Tpm1	XP_038936768.1	Tropomyosin	48..282	CDD:395200	113/234 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341556
Domainoid	1	1.000	245	1.000	Domainoid score	I2112
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48449
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8925
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.760