DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and TPM1

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_014320.1	Gene:	TPM1 / 855645	SGDID:	S000005023	Length:	199	Species:	Saccharomyces cerevisiae

Alignment Length:	218	Identity:	52/218 - (23%)
Similarity:	101/218 - (46%)	Gaps:	49/218 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 IRNELHNI----------------MNTQLKR----AESEVAALNRRIQLLEEDLERSEERLGSAT 536
            ||.:|.|:                .|..|::    .|:::.:|..:.|.||:::|:.|  .|.:.
Yeast     4 IREKLSNLKLEAESWQEKYEELKEKNKDLEQENVEKENQIKSLTVKNQQLEDEIEKLE--AGLSD 66

  Fly   537 AKLSEASQAADESERARKILENRALADEERMDALENQLKEARFLAEEA---DKKYDEVARKLAMV 598
            :|.:|......|::.....::|..|  ||.::.||.:|.|::.|:|::   ....|..::|...:
Yeast    67 SKQTEQDNVEKENQIKSLTVKNHQL--EEEIEKLEAELAESKQLSEDSHHLQSNNDNFSKKNQQL 129

  Fly   599 EADLERAEERAEQGENKIVELEEELRVVGNNLKSLEVSEEKA---NQREE-EYKNQIKTLNTRLK 659
            |.||       |:.:.|:.|..|:||  .::||:.::....|   .|||| |.||:
Yeast   130 EEDL-------EESDTKLKETTEKLR--ESDLKADQLERRVAALEEQREEWERKNE--------- 176

  Fly   660 EAEARAEFAERSVQKLQKEVDRL 682
            |...:.|.|::.:.::...::.|
Yeast   177 ELTVKYEDAKKELDEIAASLENL 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	38/137 (28%)
TPM1	NP_014320.1	Tropomyosin_1	7..186	CDD:403808	48/200 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19269
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000