DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and TPM3

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001351608.1	Gene:	TPM3 / 7170	HGNCID:	12012	Length:	285	Species:	Homo sapiens

Alignment Length:	336	Identity:	146/336 - (43%)
Similarity:	203/336 - (60%)	Gaps:	60/336 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 KKKKREKGERSEKSDKSEKSDRKKKSSGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436
            ||.:..|.::....|::|:::.::|.:  :||||      |..|.||      |:.:.:...:|:
Human     7 KKMQMLKLDKENALDRAEQAEAEQKQA--EERSK------QLEDELA------AMQKKLKGTEDE 57

  Fly   437 DNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMN 501
            .::.:|  .|:...|..|: ||::|       ||
Human    58 LDKYSE--ALKDAQEKLEL-AEKKA-------AD------------------------------- 81

  Fly   502 TQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEER 566
                 ||:|||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|::|||||.|||:
Human    82 -----AEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEK 141

  Fly   567 MDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLK 631
            |:..|.|||||:.:|||||:||:||||||.::|.||||.|||||..|:|..||||||:.|.||||
Human   142 MELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLK 206

  Fly   632 SLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDI 696
            |||...||.:|:|::|:.:||.|..:|||||.|||||||||.||:|.:|.|||.|...||.:...
Human   207 SLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCT 271

  Fly   697 GDDLDTAFVEL 707
            ...||...::|
Human   272 QRMLDQTLLDL 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	82/130 (63%)
TPM3	NP_001351608.1	Tropomyosin	49..283	CDD:395200	131/280 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147730
Domainoid	1	1.000	247	1.000	Domainoid score	I2154
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2689
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8448
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	LDO	PTHR19269
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2857
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790