DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and Tpm3

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001280677.2	Gene:	Tpm3 / 59069	MGIID:	1890149	Length:	285	Species:	Mus musculus

Alignment Length:	336	Identity:	149/336 - (44%)
Similarity:	209/336 - (62%)	Gaps:	60/336 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 KKKKREKGERSEKSDKSEKSDRKKKSSGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436
            ||.:..|.::....|::|:::.::|.:  :||||      |..|.|||      :.:.:...:|:
Mouse     7 KKMQMLKLDKENVLDRAEQAEAEQKQA--EERSK------QLEDELAT------MQKKLKGTEDE 57

  Fly   437 DNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMN 501
            .::.:|  .|:...|..|: ||::|       ||
Mouse    58 LDKYSE--ALKDAQEKLEL-AEKKA-------AD------------------------------- 81

  Fly   502 TQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEER 566
                 ||:|||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|::|||||.|||:
Mouse    82 -----AEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEK 141

  Fly   567 MDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLK 631
            |:..|.|||||:.:|||||:||:||||||.::|.||||.|||||..|:|..||||||:.|.||||
Mouse   142 MELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLK 206

  Fly   632 SLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDI 696
            |||...||.:|:|::|:.:||.|..:|||||.|||||||||.||:|.:|.|||:|..:|.:||.|
Mouse   207 SLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAI 271

  Fly   697 GDDLDTAFVEL 707
            .|:||.|..::
Mouse   272 SDELDHALNDM 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	82/130 (63%)
Tpm3	NP_001280677.2	CLZ	14..73	CDD:406832	16/74 (22%)
Tpm3	NP_001280677.2	Tropomyosin	49..283	CDD:395200	134/280 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837807
Domainoid	1	1.000	248	1.000	Domainoid score	I2128
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2662
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8688
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	LDO	PTHR19269
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2857
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780