DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and tpm1

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001280097.1	Gene:	tpm1 / 393908	ZFINID:	ZDB-GENE-040426-854	Length:	284	Species:	Danio rerio

Alignment Length:	335	Identity:	147/335 - (43%)
Similarity:	203/335 - (60%)	Gaps:	58/335 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 KKKREKGERSEKSDKSEKSDRKKKSSGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDDD 437
            |||.:    ..|.||....||.:::.|.|:.:      |..|..|..||.  |:.:.:...:|:.
Zfish     5 KKKMQ----MLKLDKENALDRAEQAEGDKKAA------EDRSKQLEDDLL--ALQKKLKGTEDEL 57

  Fly   438 NQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMNT 502
            ::.:|  .|:...|..|: ||::|                     :|
Zfish    58 DKYSE--ALKDAQEKLEL-AEKKA---------------------TD------------------ 80

  Fly   503 QLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEERM 567
                ||.:||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|::|||||.|||:|
Zfish    81 ----AEGDVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKM 141

  Fly   568 DALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLKS 632
            :..|.|||||:.:|||||:||:||||||.:||.:|||.|||||..|:|..||||||:.|.|||||
Zfish   142 EIQEIQLKEAKHIAEEADRKYEEVARKLVIVEGELERTEERAELNESKCSELEEELKTVTNNLKS 206

  Fly   633 LEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDIG 697
            ||...||.:|:|::|:.:||.|..:|||||.|||||||||.||:|.:|.|||:|..:|.:||.|.
Zfish   207 LEAQAEKYSQKEDKYEEEIKVLTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYSQKLKYKAIS 271

  Fly   698 DDLDTAFVEL 707
            ::||.|..::
Zfish   272 EELDHALNDM 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	82/130 (63%)
tpm1	NP_001280097.1	Tropomyosin	48..282	CDD:278679	131/280 (47%)
tpm1	NP_001280097.1	TMPIT	180..>274	CDD:285135	55/93 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581556
Domainoid	1	1.000	245	1.000	Domainoid score	I2136
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2703
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm6508
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	LDO	PTHR19269
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2857
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790