DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and Pnn

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001102493.1	Gene:	Pnn / 368070	RGDID:	1597086	Length:	729	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	90/411 - (21%)
Similarity:	154/411 - (37%)	Gaps:	111/411 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 DEGASNPAAALIAEDAAPPAGTTTSKSKKKKREKGERSEKSDKSEKSDRKKKS--SGKKERSKRS 407
            |.|...||.....|.|....|    ..::.:||..:.|:..|...|....:.|  :..|||::|.
  Rat    67 DSGGGPPAKQRDLEGAVSRLG----GERRTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRD 127

  Fly   408 NPMEQSSDSLATDLSA---GAIDEGIALADDDDNQAAEWSKLRCTSE-AAEIVAEREARRNKGRC 468
            ...:|:.|......:.   |.:...:.....:...|.|..|.|...| ..|:.||.|.::
  Rat   128 LIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQ----- 187

  Fly   469 ADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMNTQLKRAESEVAALNRRIQLLEEDLERSEE--- 530
                                   :.||...:.. :.:..::|:..|.::::|.:...|.:|.
  Rat   188 -----------------------VENERRELFE-ERRAKQTELRLLEQKVELAQLQEEWNEHNAK 228

  Fly   531 ------------------RLGSATAKLSEASQAADESERARKILENRALADEERMDALENQLKEA 577
                              |:..||.||.|.||     .:...:.|.|.:...|:::.:     ||
  Rat   229 IIKYIRTKTKPHLFYIPGRMCPATQKLIEESQ-----RKMNALFEGRRIEFAEQINKM-----EA 283

  Fly   578 RFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLKSLEV------- 635
            |...:...:|..:|.|          ..|::|||.|.|:.:.||||...||....:|:
  Rat   284 RPRRQSMKEKEHQVVR----------NEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEE 338

  Fly   636 -------SEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDL--VLEK- 690
                   |:.:.:|.|||.|          :|.|||.| .|..|::.:|:.|...:::  |||.
  Rat   339 KEAGVVHSDAEKDQEEEEQK----------QETEARME-EETGVREGEKQQDSQPEEVMDVLEMV 392

  Fly   691 ERYKDI---GDDLDTAFVELI 708
            |..|::   .:.::|..||.|
  Rat   393 ESVKNVIAEQEVMETNQVESI 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	38/165 (23%)
Pnn	NP_001102493.1	Pinin_SDK_N	5..132	CDD:282542	17/68 (25%)
		Pinin_SDK_memA	136..261	CDD:282541	25/158 (16%)
		FAM75	<491..>537	CDD:291323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000