DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and tpm4b

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	XP_017213161.1	Gene:	tpm4b / 324244	ZFINID:	ZDB-GENE-030131-2964	Length:	284	Species:	Danio rerio

Alignment Length:	336	Identity:	133/336 - (39%)
Similarity:	198/336 - (58%)	Gaps:	60/336 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 KKKKREKGERSEKSDKSEKSDRKKKSSGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436
            ||.:..|.::....|::|:::..||::..|        .:|..|.|.      .:.:.:...:|:
Zfish     6 KKMQMLKLDKENAIDRAEQAESDKKAAEDK--------CKQLEDELL------GLQKKLKATEDE 56

  Fly   437 DNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMN 501
            .::.:|  .|:...|..|: :|::|                     ||
Zfish    57 LDKYSE--ALKDAQEKLEL-SEKKA---------------------SD----------------- 80

  Fly   502 TQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEER 566
                 ||.:||||||||||:||:|:|::|||.:|..||.||.:|||||||..|::||||:.|||:
Zfish    81 -----AEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGIKVIENRAMKDEEK 140

  Fly   567 MDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLK 631
            |:..|.|||||:.:||::|:||:||||||.::|.:|||||||||..|.|..:|||||:.|.||||
Zfish   141 MEIQEIQLKEAKHIAEDSDRKYEEVARKLVILEGELERAEERAEIAELKGGDLEEELKNVTNNLK 205

  Fly   632 SLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDI 696
            |||...||.:::|::|:::||.|..:|||.|.|||||||:|.||:|.:|.||:.|...|::..::
Zfish   206 SLEAQSEKYSEKEDKYEDEIKVLTDKLKEVETRAEFAERTVAKLEKTIDDLEESLGEAKQQNLEM 270

  Fly   697 GDDLDTAFVEL 707
            ...||....||
Zfish   271 HQVLDQTLQEL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	77/130 (59%)
tpm4b	XP_017213161.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581564
Domainoid	1	1.000	245	1.000	Domainoid score	I2136
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2703
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6508
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.000